a green and efficient one-pot, four-component synthesis of 6-amino-4-aryl-3-methyl-2,4-dihydropyrano[2,3- c ]pyrazo-carbonitrile derivatives catalyzed by borax in water is described. this method provides several advantages such as environmental friendliness, shorter reaction time, excellent yields, and simple workup procedure. the in vitro cytotoxic activity of the synthesized test compounds wa...

hop stunt viroid (hsvd) isolates have been reported as the causal agent of citrus cachexia in mazandaran province and recently shown to be associated with yellow corky vein disease of sweet orange and split bark disorder of sweet lime in the fars province, iran. in the present work isolation and partial characterization of viroids from citrus trees affected by gummy stem blight is reported from...

The Bcl-2 oncoprotein, which is expressed in a variety of human malignancies, blocks apoptosis induced by chemotherapeutic drugs, including the topoisomerase II inhibitor, etoposide. To determine the significance of Bcl-2 in etoposide-induced death of human epithelial tumor cells, HeLa S3 cells were transfected with human bcl-2 cDNA in the pSFFV expression vector, and stable Bcl-2-expressing cl...

To overcome multidrug resistance (MDR) in cancer chemotherapy, we prepared various plant extracts and searched for a component which is effective for inhibition of MDR. MDR inhibition activity was determined by measuring cytotoxicity to MDR cells using multidrug resistant human fibrocarcinoma KB V20C, which is resistant to 20 nM vincristine and expresses high level of mdr1 gene. Of various plan...

Kampung Keluarga Berkualitas (KB) adalah satuan wilayah setingkat RW, dusun atau setara, yang memiliki kriteria tertentu dimana terdapat keterpaduan Program Pembangunan Kependudukan dan Berencana (Bangga Kencana) pembangunan sektor terkait dilaksanakan secara sistemik sistematis. Tujuan dibentuknya untuk meningkatkan kualitas hidup masyarakat di tingkat kampung setara melalui serta membangun da...

Cranesbill (Geranium species) are used traditionally as tonic, antidiabetic, antidiarrheal, antihemorrhoidal, diuretic and for the treatment of cough, fever, tonsillitis, urticaria, kidney pain and gastrointestinal ailments. The leaves of some Geranium species are consumed in traditional Turkish cousin as salad or added to pastry. In the present study, different extracts from G. psilostemon and...

cranesbill (geranium species) are used traditionally as tonic, antidiabetic, antidiarrheal, antihemorrhoidal, diuretic and for the treatment of cough, fever, tonsillitis, urticaria, kidney pain and gastrointestinal ailments. the leaves of some geranium species are consumed in traditional turkish cousin as salad or added to pastry. in the present study, different extracts from g. psilostemon and...

Paracetamol (known as acetaminophen, or APAP) poisoning causes acute liver damage that can lead to organ failure and death. We sought determine APAP overdose augment tumor necrosis factor-alpha (TNF-α)/ nuclear factor kappa B (NF-kB)/induced nitic oxide synthase (iNOS) axis-mediated hepatotoxicity in rats, the anti-inflammatory polyphenolic compounds, quercetin (QUR) plus resveratrol (RES) ame...