The antitumor drugs NB-506 and J-107088 are potent topoisomerase I inhibitors with an indolocarbazole structure. To clarify the factors involved in resistance to these drugs, we established two NB-506-resistant mouse fibroblast cell lines (LY/NR1and LY/NR2), a human colon carcinoma cell line (HCT116/NR1), and a lung cancer cell line (PC13/NR1). These cell lines were highly resistant to NB-506 a...

We have examined a promising family of radio frequency coaxial connectors (the SSMCX range) suitable for use at low temperatures. We describe the measured characteristics of these connectors in typical arrangements using lossy Cooner stainless steel inner and outer (braided) coaxial cable and other specialty low temperature coaxial cables including Beryllium Copper (BeCu) outer and inner conduc...

Abstract To reduce the cost of manufacturing tools, which are commonly made from powder steels, high-alloy tool steel in form an ingot was cast. Conventional casting allows better use recycled materials and overall reduction material production costs. This experimental then processed a semi-solid state to remove unsuitable structure obtain desired functional properties. In case it is primarily ...

The openings of Copper converter in Sarcheshmeh Copper Complex in Iranis made of a heat resisting austenitic steel (Fe-25Cr-12Ni) and many failures have been reported. Understanding the failure mechanism of the alloy helps to develop better alloys for similar complex environments. Samples of as-cast alloy and those taken from failed ones were examined. Optical Microscopy (OM), X-Ray Diffraction...

the aim of the paper presented here is to develop the ti - micralloyed steel in otrer to oprtmize the mechanical properties after direct quenching from hot forging temperature. for this purpose, seven melts containing various amounts of titanium were prepared and cast in metal and sand molds. from the ingots, cast in metal mould, tractor links were produced by hot forging. the produced links we...

Abstract The paper presents the research results on duplex corrosion-resistant chromium–nickel–molybdenum cast steel of GX2CrNiMoCuN 25-6-3-3 grade. aim was to determine effect soaking temperature for hyperquenching process T p , that is, 950 1200 °C, microstructure and mechanical properties, is UTS tensile strength, yield HB Brinell hardness, elongation EL impact strength KV steel, under indus...

Abstract: In this research, the oxidation behaviour of high Aluminum heat resistant steel (%25Cr,%20Ni,%8Al) hasbeen evaluated at the temperature range of (1000-1300ºC).The results showed that there was no countinous healinglayer on the surface of the alloy when Al increased up to %5.5 and the oxidation resistance of steel decreased due toformation of spinel oxides on the surface.By increasing ...

Abstract Al-Si wrought piston alloys can lack properties due to inefficient grain refining. A novel Al-Nb-B refiner was introduced some time ago, but has still not been assessed in industry for alloys. This paper describes the first trial of Al-Ni-B addition and its impact on full-scale manufacturing, structure, AA4032 products extruded with without billet homogenization. It is shown that Nb-B ...