An efficient strategy for the preparation of N-linked glycopeptides is described. The method relies on the use of side chain protecting groups on aspartic acid residues, namely the allyl and Dmab esters, which are orthogonal to those utilised in Fmoc-strategy SPPS. After peptide assembly these protecting groups were selectively removed and the resulting free side chains derivatised with a glyco...

Children are becoming less likely to have direct contact with nature. This ongoing loss of human interactions with nature, the extinction of experience, is viewed as one of the most fundamental obstacles to addressing global environmental challenges. However, the consequences for biodiversity conservation have been examined very little. Here, we conducted a questionnaire survey of elementary sc...

On December 15, 2010, after 11 months of legal standoff, the Swiss corporation Novartis finally closed a deal to acquire the remaining shares of eye-care company Alcon from minority shareholders. Why did it take almost a year? The acquisition had become a relatedparty transaction after Novartis purchased a 25% stake from then majority shareholder Nestlé and nominated some of its own directors t...

In face of the increasingly serious ecological crisis, this paper discusses origin and meaning a community shared life from perspective ethics, as well goodness beauty life, which is essence human natural practice in accordance with law beauty. From integration aesthetics, focusing on unity utilitarianism non-utilitarianism, new realm pursuing harmonious coexistence man nature, contains deep re...

The process of spontaneous parametric down-conversion (SPDC) in nonlinear crystals makes it fairly easy to generate entangled photon states. It has been known for some time that the conversion efficiency can be improved by employing quasi-phase-matching in periodically poled crystals. Using two single-photon detectors, we have analyzed the photon pairs generated by SPDC in a periodically poled ...