نتایج جستجو برای: natural bioactive compound

تعداد نتایج: 626583  

2017
Kendra J. Royston Neha Udayakumar Kayla Lewis Trygve O. Tollefsbol

With cancer often classified as a disease that has an important epigenetic component, natural compounds that have the ability to regulate the epigenome become ideal candidates for study. Humans have a complex diet, which illustrates the need to elucidate the mechanisms of interaction between these bioactive compounds in combination. The natural compounds withaferin A (WA), from the Indian winte...

Journal: :Journal of biomolecular screening 2016
Reka A Otvos Marija Mladic Gabriela Arias-Alpizar Wilfried M A Niessen Govert W Somsen August B Smit Jeroen Kool

The α7-nicotinic acetylcholine receptor (α7-nAChR) is a ligand-gated ion channel expressed in different regions of the central nervous system (CNS). The α7-nAChR has been associated with Alzheimer's disease, epilepsy, and schizophrenia, and therefore is extensively studied as a drug target for the treatment of these diseases. Important sources for new compounds in drug discovery are natural ext...

Journal: :International journal of cosmetic science 2015
J M Gillbro E Merinville M Olsson T Al-Bader A Klack L Visdal-Johnsen A Mavon

OBJECTIVE The need for effective 'anti-ageing' treatments, in particular for the management of photodamaged skin, prompted us to develop a novel method to identify new active ingredients. The model utilized a gene profiling study with corresponding connectivity mapping (Cmap) to identify novel anti-ageing compounds using all-trans retinoic acid (RA) as the lead compound due to its beneficial ef...

2013
Xavier Lucas Christian Senger Anika Erxleben Björn A. Grüning Kersten Döring Johannes Mosch Stephan Flemming Stefan Günther

Bacteria from the genus Streptomyces are very important for the production of natural bioactive compounds such as antibiotic, antitumour or immunosuppressant drugs. Around two-thirds of all known natural antibiotics are produced by these bacteria. An enormous quantity of crucial data related to this genus has been generated and published, but so far no freely available and comprehensive databas...

Journal: :International immunology 2002
Tomohiko Ogawa Yasuyuki Asai Masahito Hashimoto Osamu Takeuchi Tomoko Kurita Yasunobu Yoshikai Kensuke Miyake Shizuo Akira

Porphyromonas gingivalis lipopolysaccharide (LPS) and its bioactive center, lipid A, are known to exhibit very low endotoxic activities and activate LPS-hyporesponsive C3H/HeJ mice that have a point mutation in the cytoplasmic portion of Toll-like receptor (TLR) 4, in contrast to classical enterobacterial LPS and their lipid A. In the present study, we attempted to determine which TLR mediates ...

2010
Prabha Devi Solimabi Wahidullah Cheryl Rodrigues Lisette D. Souza

Several bacterial cultures were isolated from sponge Halichondria sp., collected from the Gujarat coast of the Indo Pacific region. These bacterial cultures were fermented in the laboratory (100 mL) and the culture filtrate was assayed for antibiotic activity against 16 strains of clinical pathogens. Bacillus sp. (SAB1), the most potent of them and antagonistic to several clinically pathogenic ...

2011
Stéphanie Cottier Timon Mönig Zheming Wang Jiří Svoboda Wilhelm Boland Markus Kaiser Erich Kombrink

Chemical genetics is a powerful scientific strategy that utilizes small bioactive molecules as experimental tools to unravel biological processes. Bioactive compounds occurring in nature represent an enormous diversity of structures that can be used to dissect functions of biological systems. Once the bioactivity of a natural or synthetic compound has been critically evaluated the challenge rem...

2017
Kendra J. Royston Neha Udayakumar Kayla Lewis Trygve O. Tollefsbol

With cancer often classified as a disease that has an important epigenetic component, natural compounds that have the ability to regulate the epigenome become ideal candidates for study. Humans have a complex diet, which illustrates the need to elucidate the mechanisms of interaction between these bioactive compounds in combination. The natural compounds withaferin A (WA), from the Indian winte...

2009
Isolde Wetzel Franz Bracher Jürgen Krauss

Isocoumarins are a large and structurally diverse class of bioactive natural products with widespread occurance in living organisms [1], and considerable work has been published over decades about their chemistry [2] and biology [3]. A considerable number of natural and synthetic isocoumarins showed significant cytotoxic and antitumor activity. Among those are dihydroisocoumarins like AI-77-B (...

2009
Sheetal Verma

Nature always stands as a golden mark to exemplify the outstanding phenomena of symbiosis. In the western world, as the people are becoming aware of the potency and side effect of synthetic drugs, there is an increasing interest in the natural product remedies with a basic approach towards the nature. Throughout the history of mankind, many infectious diseases have been treated with herbals. A ...

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