Prolonged residence of drug formulation in the nasal cavity is important for the enhancing intranasal drug delivery. The objective of the present study was to develop a mucoadhesive in-situ gelling nasal insert which would enable the reduced nasal mucociliary clearance in order to improve the bioavailability of metoclopramide hydrochloride. Metoclopramide hydrochloride is a potent antiemetic...

We used a computational fluid dynamics (CFD) model to study the inspiratory airflow profiles of patients with anterior nasal cavity stenosis who underwent curative surgery, by comparing pre- and postoperative airflow characteristics. Twenty patients with severe anterior nasal cavity stenosis, including one case of bilateral stenosis, underwent computed tomography (CT) scans for CFD modelling. T...

IMPORTANCE The internal nasal valve is the narrowest part of the nasal airway and a common site of inspiratory collapse and obstruction of nasal airflow. Over-the-counter mechanical nasal dilators are an alternative to surgical intervention that attempts to improve airflow through the internal nasal valve. OBJECTIVE To determine the efficacy of over-the-counter mechanical nasal dilators and c...

The functions of the nasal cavity are closely related to its structure. In this study the three-dimensional finite element models were established based on the clinical data of twenty-four volunteers to study the influence of nasal structure on nasal functions of heating the inhaled airflow. Numerical simulations mainly concerning the airflow distribution and the airflow temperature are perform...

Nose is one of the most important aesthetic unit of the face.Management of nasal trauma plays a significant role in the practices of the majority of facial and reconstructive surgeons. Replantation, although technically very challenging, is undoubtedly the procedure of choice following traumatic nasal amputation. Here we present an illustrative case report of the traumatic amputation of a nasal...

The ventilatory controlling factors associated with oral augmentation of nasal breathing were investigated in 25 (14 women, 11 men) healthy adults during an incrementally graded bicycle exercise test. Ventilatory variables were measured by separate oral and nasal pneumotachometers integrated with a valveless oral-nasal face mask and a flexible oral catheter. Inspired and expired breath length, ...

The nasal cavity volume and the temperature of the nasal mucosa are considered to be the most important predictors of nasal conditioning. The aim of this study was to assess the relationship between the intranasal degree of water vapour saturation of inhaled air and nasal patency. Intranasal humidity values at different locations within the nasal cavity of 15 healthy subjects were compared to n...

One of the simple and economical diagnostic methods in detecting nasal allergic disorders is cytological examination of nasal smears. This study was conducted to evaluate the usefulness of nasal cytology in individuals suffering from allergic nasal disorders, including allergic nasal polyps with special interest on cytohistological correlation in case of allergic nasal polyps. Effort is also ma...