Anti-tumor necrosis factor (TNF)-α antibody is utilized in the treatment of a variety of chronic inflammatory conditions, including psoriasis. However, it can induce paradoxical development and/or exacerbation of psoriasis in the course of anti-TNF-α antibody treatment, which is sometimes refractory to conventional treatments. Herein, we report a case of refractory palmoplantar pustular psorias...

Psoriasis is a common disease in children and adolescents. Because of the chronic course of the disease, appropriate choice of therapy in particular stage of the disease, so-called rotation therapy, is of paramount importance. This article provides a review of therapeutic options for childhood psoriasis. Local therapy for psoriasis in children consists of corticosteroid preparations, calcipotri...

The coexistence of atopic dermatitis (AD) and psoriasis has been not impossible, because their respective immunological situations involve distinct reactions. Recently, there are some reports of comorbidity of AD and psoriasis. Here we present the case of a patient with AD who developed psoriasis. A 43-year-old female developed AD, and new erythema has increased over 40 years. The results of sk...

Vitiligo is an acquired skin disorder caused by the disappearance of pigment cells from the epidermis, and results in well defined white patches that are often symmetrically distributed. The lack of melanin pigment makes the lesional skin more sensitive to sunburn. Vitiligo can be cosmetically disfiguring and is a stigmatizing condition, leading to serious psychological problems in daily life. ...

Topical immunotherapy, defined as the induction and periodic elicitation of an allergic contact dermatitis by topical application of potent contact allergens, has been used to treat conditions such as alopecia areata (AA) and recalcitrant warts since the 1970s (1). Topical immunotherapy with diphenylcyclopropenone (DPCP) is a safe and sometimes effective treatment for chronic extensive AA and v...

Narrow-Band Ultraviolet B (NB-UVB) in combination with topical therapy is a widely used treatment for non-segmental vitiligo (NSV). The location of the lesions influence on potential repigmentation response after therapy. To date however, these differences therapeutic between specific anatomical areas body have not been fully characterized. This study aimed to evaluate clinical NB-UVB 19 differ...

Treatment for vitiligo is difficult and prolonged. Nevertheless, at present considerable knowledge accumulated during several decades on the pathogenic mechanisms, revealed important clues for designing new strategies to improve vitiligo depigmentation. With available medical therapies, high repigmentation percentages mostly on facial and neck lesions are achieved, although they are less effect...