Experiments were performed in order to obtain physiological evidence for the presence of delta opioid receptors in the guinea pig isolated ileum. The nonequilibrium narcotic antagonists beta-chlornaltrexamine (beta-CNA) and beta-funaltrexamine (beta-FNA) differentially affected inhibitory responses to mu- and delta-specific opiate ligands (q value). These results indicate that these agonists do...

Background Pain, although invariably present after surgical procedures, is not always well controlled. Medications from different analgesic groups are often used to control post-operative pain. Recently, attention has turned towards the optimization of non-opioid analgesics including NSAIDS and acetaminophen. After gynaecologic laparoscopy up to 80% of patients may require opioid analgesia. How...

A follow-up study of girls in a London remand home during the years 1966-8 showed that 20.6% of those taking non-narcotic drugs on admission, but only 1% of non-drug-taking control admissions, had used narcotics by June 1970. Narcotic use on admission and progression to narcotic use were associated with frequent drug taking, marked involvement in a drug milieu, and a high incidence of personal ...

OBJECTIVE To document the incidence of neonatal abstinence syndrome (NAS) and the rate of narcotic use during pregnancy in northwestern Ontario, where narcotic abuse is a growing social and medical problem. DESIGN Retrospective chart review. SETTING The Sioux Lookout Meno Ya Win Health Centre catchment area in northwestern Ontario. PARTICIPANTS Mothers and neonates for the 482 live births...

Narcotic substitution is now widely used. Morphine can induce a spasm of the sphincter of Oddi but dilation of bile duct has been reported only in an anecdotal case. In June 1995, we observed a first case of dilation of the common bile duct without organic obstacle in a hepatitis C virus (HCV)-infected patient who was under narcotic substitution, suggesting a causal relationship. We conducted a...

Clavicle fractures are common in adults. Recent studies have shown that operative treatment of clavicle fractures has benefits in many situations. However, there is controversy about the indications. Data on social outcomes are limited. A total of 434 patients with 436 clavicle fractures treated both operatively and nonoperatively at a level 1 trauma center were identified. Narcotic use was rec...

Methods Longmont United Hospital (LUH) is a 146 bed institution in Boulder County, Colorado. The intensive care unit is a sixteen-bed combined medical-surgical facility that provides care to any critically ill patient at LUH. Admissions were prospectively studied from January through March of 2015. Patients were evaluated for age, sex, prescription opioid use, and for the type of assisted venti...