Jab1 (Jun activation domain binding protein 1), integrated into COP9 signalosome complex (CSN), induces protein instability of many tumor suppressors and cell cycle regulators and is therefore a novel target in cancer therapy. Curcumin, an inhibitor of Jab1/CSN-associated kinase(s), has been reported to suppress tumor growth; however, curcumin is highly hydrophobic, and this feature prevents it...

To the Editors: The recent interesting article by Dhillon et al. (1) evaluated the clinical biological effects of curcumin against advanced pancreatic cancer. One important puzzle arising from this study involves how the biological activities are done with the precondition of the low nanogram levels of circulating curcumin (only 22-41 ng/mL were detectable in plasma even at oral dose of 8 g/d; ...

background and objectives: colorectal cancer is the third most common cancer and a major cause of morbidity globally. hepatocellular carcinoma is a leading cause of death in the world. about 80% of all anticancer drugs are somehow related to natural products. one of the most important of these natural compounds is curcumin, the main component of turmeric that has a wide range of pharmacological...

curcumin is a hydrophobic polyphenol extracted from the plant curcuma longa with establishedanticancer properties. however, curcumin benefits have been impaired by its very low watersolubility, low absorption, rapid metabolism and clearance from the body. recently,nanotechnology promises to be helpful in development of drugs delivery systems by recentadvances in macromolecular design of nanocar...

objective: curcumin is a major constituent of turmeric and has many biological functions such as anticancer and anti-inflammatory effects. the present study was conducted to investigate the effects of curcumin and diazepam in separate and combined treatments on penicillin-induced seizures in rats. materials and methods: in urethane-anesthetized rats, epileptiform activity was induced by intraco...

Cancer is a leading cause of death worldwide, and most the currently available drugs for cancer treatment have limited potential. Natural products their relatives continue to represent very high percentage used treatment. Curcumin one several natural that has recently attracted much attention due its putative cancer-preventive anticancer properties. As well, Nitric Oxide (NO) holds great potent...

introduction: curcumin is the active ingredient in the traditional herbal remedy and dietary spice turmeric (curcuma longa). curcumin has a surprisingly wide range of beneficial properties, including anti-inflammatory, antioxidant, chemopreventive and chemotherapeutic activity. on basis of recent studies; it has antifungal and antibacterial effects. the aim of this study was in-vitro evaluation...

Curcumin, a well-known dietary pigment derived from Curcuma longa, inhibited growth of several types of malignant cells both in vivo and in vitro. However, its mechanism of action still remains unclear. In this study, we have focused primarily on the cytotoxic effects of curcumin on three human tumor cell lines and rat primary hepatocytes. Curcumin induced apoptosis in MCF-7, MDAMB, and HepG2 c...

Curcumin protects the skin against radiation-induced epidermal damage and prevents morphological changes induced by irradiation skin, thereby maintaining the epidermal thickness and cell density of basal layers. In this study, the effects of topical curcumin treatment on radiation burns were evaluated in a mini-pig model. Histological and clinical changes were observed five weeks after radiatio...

Curcumin (diferuloylmethane), the yellow pigment in turmeric (Curcuma longa), is known to inhibit proliferation of cancer cells by arresting them at various phases of the cell cycle and to induce apoptosis in tumor cells. Curcumin-induced apoptosis mainly involves the activation of caspase-3 and mitochondria-mediated pathway in various cancer cells of different tissue origin. In the present stu...