Objecttive(s): Despite the poor mechanical properties of hydroxyapatite, its unique biological properties leads we think about study on improving its properties rather than completely replacing it with other biomaterials. Accordingly, in this study we introduced hydroxyapatite reinforced with hardystonite as a novel bio-nanocompositeand evaluate its in-vitro bioactivity with the aim of developi...

The regeneration of functional tissue in osseous defects is a formidable challenge in orthopedic surgery. In the present study, a novel biomimetic composite scaffold, here called nano-hydroxyapatite (HA)/poly-ε-caprolactone (PCL) was fabricated using a selective laser sintering technique. The macrostructure, morphology, and mechanical strength of the scaffolds were characterized. Scanning elect...

The failure of prosthesis after total joint replacement is due to the lack of early implant osseointegration. In this study polyvinyl alcohol-collagen-hydroxyapatite (PVA-Col-HA) electrospun nanofibrous meshes were fabricated as a biomimetic bone-like extracellular matrix for the modification of orthopedic prosthetic surfaces. In order to reinforce the PVA nanofibers, HA nanorods and Type I col...

In this work, we report the effect of biopolymers (starch and gelatin) on in vitro biocompatibility property of nano hydroxyapatite (nHAp) composites. Cell culture and MTT assays were performed for in vitro biocompatibility. They show that nHAp can affect the proliferation of cells and the nHAp-starch and nHAP-gelatin biocomposites have no negative effect on the cell morphology, viability and p...

Hydroxyapatite is the major mineral component of human bones. From the point of view of its chemistry, it is calcium orthophosphate which has in its structure hydroxyl groups and in its stoichiometric is described with formula – Ca10(PO4)6(OH)2. Biological properties of hydroxyapatite are very favorable; it is not only biocompatible (which means that after implantation it causes no side effects...

A new method was used in fixation of tibial bone fractures. Intramadular nailing (IMN) has been used into mid-diaphysis on left tibias of New Zeland rabbits (n = 5) via an in vivo work. To enable fixation of fracture, without causing too much screw damage on bone and avoiding malunion, nano- and micro-scale hydroxyapatite (HA) was coated at two ends (25 mm in length) of intramadular nails befor...

In the present study, functionalized bioresorbable nanomaterials (less than 50 nm in size) were formulated to specifically attach to cancerous (not healthy) bone to form an implant used to treat bone cancer. After attachment, sustained release of anti-cancer agents occurred at targeted sites. Specifically, inorganic biodegradable nanomaterials (including ceramics like hydroxyapatite or HA) were...