Macrophages play an important role in the development of age-related macular degeneration (AMD). In this study, the spatial and temporal changes and the polarization of macrophages in murine laser-induced choroidal neovascularization (CNV) were investigated, and the polarized M1 and M2 biomarkers in the aqueous humors of neovascular AMD (nAMD) patients were studied. Macrophages, the main infilt...

Ranibizumab is an antibody fragment (Fab) that binds and inhibits all isoforms of vascular endothelial growth factor (VEGF), which is considered the main target in neovascular age-related macular degeneration (naMd). Based on scientific evidence of the anti-VEGF antibody for the Treatment of Predominantly classic choroidal Neovascularization in aMd (aNchoR)/Minimally classic/occult Trial of the...

Purposes To compare the effects of aflibercept and other anti-vascular endothelial growth factor (anti-VEGF) medications on both functional and anatomical outcomes for treatment-naïve neovascular age-related macular degeneration (nAMD) in the real world. Methods A systematic review and meta-analysis of observational comparative studies. Results A total of 18 studies remained after literatur...

PURPOSE The purpose of this study was to evaluate the treatment efficacy of vitrectomy combined with subretinal recombinant tissue plasminogen activator (r-tPA) and factors affecting visual improvement in patients with submacular hemorrhage (SMH) due to neovascular age-related macular degeneration (nAMD). MATERIALS AND METHODS Medical records of 17 consecutive patients diagnosed with SMH seco...

Purpose An independent Safety Review Committee (SRC), supported by Novartis Pharma AG, analyzed investigator-reported cases of intraocular inflammation (IOI), endophthalmitis, and retinal arterial occlusion in the phase 3 HAWK HARRIER trials brolucizumab versus aflibercept neovascular age-related macular degeneration (nAMD). Design A post hoc analysis a subset data from two 2-year, double-maske...

Introduction Several diagnostic tests are often adopted into pathways for specific indications without strong evidence to support their use. In this context, real-world prospective cohort studies in combination with decision modelling can generate decision-making. The Early Detection of neovascular Age-Related Macular Degeneration (EDNA) study was a designed assess the accuracy and cost-effecti...