نتایج جستجو برای: naloxone

تعداد نتایج: 4623  

Journal: :Pain physician 2015
Yury Khelemsky Rishi Kothari Neville Campbell Shahbaz Farnad

BACKGROUND Perioperative use of opioids is associated with the risk of opioid-induced respiratory depression. Naloxone is a competitive opioid antagonist typically administered to reverse opioid-induced respiratory depression. Postoperative administration of naloxone may be considered a proxy for significant postoperative opioid-induced respiratory depression and data regarding its use may be u...

Journal: :North Carolina Medical Journal 2018

Journal: :Journal of the experimental analysis of behavior 1975
D A Downs J H Woods

Lever pressing by rhesus monkeys was maintained by morphine injections during four equally spaced sessions each day. During other periods, lever pressing was maintained by timeout from a continuous naloxone infusion (escape), or by timeout from a stimulus that preceded naloxone injections, or termination of the injections (avoidance-escape). As naloxone dose increased in the escape procedure, r...

Journal: :Human reproduction 1998
M Bondanelli M R Ambrosio P Franceschetti R Guerrini A Valentini E C degli Uberti

There is evidence that endogenous opioid peptides exert an inhibitory effect on pituitary luteinizing hormone (LH) secretion both in animals and in humans, by interacting with mu-opioid receptors. However, a role for delta-opioid receptors in the regulation of gonadotrophin releasing hormone (GnRH) secretion has recently been suggested. In the present study, we evaluated the effect of the highl...

Journal: :Acta neurobiologiae experimentalis 2005
Tomasz Misztal Katarzyna Romanowicz

This study was designed to test the hypothesis that melatonin would intensify daily LH release after central blockade of the opiate receptors in sexually active ewes. The intracerebroventricular infusions of vehicle (control), melatonin, naloxone and melatonin in combination with naloxone were made in ewes in the luteal phase of the estrous cycle, from 2:00 P.M. to 5:00 P.M. Blood samples were ...

2012
Tinh Nguyen

–Opioid overdose is a potentially life-threatening condition that requires immediate medical attention, often landing affected individuals into the emergency department. The longstanding treatment for opioid overdose has been naloxone, a pure opioid antagonist that reverses all signs of opioid intoxication. While effective as a reversal agent, naloxone has a half-life which is shorter than all ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2007
S L Chen H I Ma J M Han P L Tao P Y Law H H Loh

We previously reported that mutations in the mu-opioid receptor (MOR), S196L or S196A, rendered MOR responsive to the opioid antagonist naloxone without altering the agonist phenotype. Subsequently, a mouse strain carrying the S196A mutation exhibited in vivo naloxone antinociceptive activity without the development of tolerance. In this study we investigated the possibility of combining the in...

2015
Rebecca E Giglio Guohua Li Charles J DiMaggio

The objective of this review was to assess the effectiveness of bystander naloxone administration and overdose education programs by synthesizing quantitative results reported in the research literature. Studies meeting predefined criteria were identified and reviewed, and their results were synthesized through meta-analysis. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated ...

2013
Katherine N.H. Johnson Nurulain Zaveri Kalpna Gupta

M.-O. Parat (ed.), Morphine and Metastasis, DOI 10.1007/978-94-007-5678-6_2, © Springer Science+Business Media Dordrecht 2013 Abstract Majority of breast cancers are estrogen receptor (ER) positive. Due to resistance to known ER-based therapies, novel treatment targets and drugs are required to effectively treat ER-positive breast cancer. Opioids are often used to treat pain in breast cancer an...

Journal: :Archives of general psychiatry 1998
G S Wand D Mangold S El Deiry M E McCaul D Hoover

BACKGROUND This study was designed to assess whether nonalcoholic offspring from families with a high density of alcohol-dependent individuals have altered endogenous central nervous system opioid activity. Naloxone hydrochloride stimulates plasma cortisol by blocking opioidergic input on the corticotropin-releasing factor neuron, thereby providing a noninvasive method for measuring hypothalami...

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