Local angiotensin II (AII) and sirtuin 1 (SIRT1) play a major role in the modulation of neuroinflammation, oxidative stress and aging-related dopaminergic vulnerability to damage. However, it is not known whether the modulation is related to reciprocal regulation between SIRT1 and AII. In the present study, a single intraventricular injection of AII increased nigral SIRT1 levels in young adult ...

The fifth chapter of the series about Rudolf Schlechter’s South-American orchids introduces us to those botanists and orchid collectors who travelled worked in Ecuador Peru supplied Schlechter with many new species he described. As previous chapters, biographies accomplishments these travellers are preceded by brief geographical historical outlines for each countries. It is worth mentioning tha...

The site on influenza virus N9 neuraminidase recognized by NC41 monoclonal antibody comprises 19 amino acid residues that are in direct contact with 17 residues on the antibody. Single sequence changes in some of the neuraminidase residues in the site markedly reduce antibody binding. However, two mutants have been found within the site, Ile368 to Arg and Asn329 to Asp selected by antibodies ot...

An external quality assessment (EQA) program for the molecular detection of avian influenza A (H7N9) virus was implemented by the National Center for Clinical Laboratories (NCCL) of China in June 2013. Virus-like particles (VLPs) that contained full-length RNA sequences of the hemagglutinin (HA), neuraminidase (NA), matrix protein (MP), and nucleoprotein (NP) genes from the H7N9 virus (armored ...

Prakriya, Murali and Christopher J. Lingle. Activation of BK channels in rat chromaffin cells requires summation of Ca influx from multiple Ca channels. J Neurophysiol 84: 1123–1135, 2000. Large-conductance Ca and voltage-dependent K channels (BK channels) in many tissues require high Ca concentrations for activation and therefore might be expected to be tightly coupled to Ca channels. However,...

INTRODUCTION HTLV-I Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a progressive Myelopathy that mainly involves the corticospinal tract. Despite pronounced involvement of the lower limbs, patients also have abnormalities in their upper limbs. So, we studied somatosensory-evoked potentials (SSEPs) of the median nerve in HAM/TSP patients to determine the extent of the involvemen...

It has been widely accepted that microglia, the innate immune cells in the brain, can be chronically activated in response to neuron death, fuelling a self-renewing cycle of microglial activation followed by further neuron damage (reactive microgliosis), which has been considered as the main reason responsible for the progressive nature of neurodegenerative diseases. In the present study, it wa...

The digold complex [Au2(l-G)(l-dmpe)](KBr)0:75 2H2O (dmpe1⁄4 1,2-bis(dimethylphosphino)ethane (1)) has been prepared by nucleophilic attack of the guaninate dianion on the gold(I) atoms of [(AuBr)2(l-dmpe)] and has been characterised by X-ray crystallography and spectroscopic studies. The structure of 1 consists of dinuclear nine-membered ring molecules, Kþ cations, Br anions and water molecule...