n7 Readers will perhaps notice that the familar name of Dr. Philip Alan Maplestone, d.s.o., d.sc., m.b.j ch.B., d.t.m., does not appear this month on our cover. Earlier in this year, when the Japanese threat to Australia was developing rapidly, Dr. Maplestone decided that in the circumstances he ought to return to Australia where his wife and family were living. He took four months' leave, but ...

This communication explores the effect of varying substituent bulk at the N9 position of the adenine moiety and its effect in dictating the structural aspects of silver-adenine frameworks. While adenine alone or 9-benzyl substituted ligand afforded mono and dinuclear dimeric entities, n-propyl substitution at the N9 position results in the formation of a metallaquartet. Longer n-alkyl chains (h...

Multidrug-resistant clinical isolate Klebsiella pneumoniae BM4686 was highly resistant to 4,6-disubstituted 2-deoxystreptamines and to fortimicin. Resistance was due to the presence, on the 40-kb non-self-transferable plasmid pIP849, of the rmtF gene which was cotranscribed with the upstream aac(6')-Ib gene. The deduced RmtF protein had 25 to 46% identity with members of the N7 G1405 family of ...

Department of Chemistry, UniVersity of New Brunswick, P.O. Box 4400, Fredericton, N.B. E3B 5A3, Canada, Department of Health and Human Sciences, London Metropolitan UniVersity, 166-220 Holloway Road, London N7 8D8, U.K., Forschungsneutronenquelle Heinz Maier-Leibnitz (FRM-II), Technische UniVersität München, D-85747 Garching, Germany, CNR-ISTM, Istituto di Scienze e Tecnologie Molecolari, Via C...

The in vitro antiproliferative activity of the title compound on five tumor cell lines shows preference for the colon-rectal tumor HCT116, IC(50) = 13.98 μM, followed by breast MCF7 (19.58 μM) and ovarian A2780 (23.38 μM) cell lines; human glioblastoma U-87 and lung carcinoma A549 are less sensitive. A commercial curcumin reagent, also containing demethoxy and bis-demethoxy curcumin, was used t...

N7-Methyl-2'-deoxyguanosine (m7dG) is the predominant lesion formed by methylating agents. A systematic investigation on the effect of m7dG on DNA replication has been difficult due to the chemical instability of m7dG. To gain insights into the m7dG effect, we employed a 2'-fluorine-mediated transition-state destabilzation strategy. Specifically, we determined kinetic parameters for dCTP insert...

The dinucleotide d(pGpG) is an often employed DNA model to study various kinds of interactions between DNA and metal ions, but its acid-base properties were not yet described in detail. In this study the six deprotonation reactions of H4[d(pGpG)]+ are quantified. The acidity constants for the release of the first proton from the terminal P(O)(OH)2 group (pKa = 0.65) and for one of the (N7)H+ si...