Precisely regulated expression of oncogenes and tumor suppressor genes is essential for normal development, and deregulated expression can lead to cancer. The human N-myc gene normally is expressed in only a subset of fetal epithelial tissues, and its expression is extinguished in all adult tissues except transiently in pre-B lymphocytes. The N-myc gene is overexpressed due to genomic amplifica...

ADPKD (Autosomal Dominant Polycystic Kidney Disease) is characterized by the progressive expansion of multiple cystic lesions in the kidneys. ADPKD is caused by mutations in Ed-pl. consider PKD1 and PKD2. Recently a relation between c-myc and the pathogenesis of ADPKD was reported. In addition, c-Myc is a downstream effector of PKD1. To identify the gene regulated by PKD2 and c-Myc, we performe...

N-myc downstream regulated gene 1 (NDRG1) has been well characterised to act as a metastatic suppressor in a number of human cancers. It has also been implicated to have a significant function in a number of physiological processes such as cellular differentiation and cell cycle. In this review, we discuss the role of NDRG1 in cancer pathology. NDRG1 was observed to be downregulated in the majo...

N-myc downstream-regulated gene 1 (NDRG1), has been identified as an important metastasis suppressor for colorectal cancer (CRC). In this study, we investigated: (1) the effects of NDRG1 on CRC stemness and tumorigenesis; (2) the molecular mechanisms involved; and (3) the relationship between NDRG1 expression and colorectal cancer prognosis. Our investigation demonstrated that CRC cells with si...

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 204 No. 7 1219–1236 www.jcb.org/cgi/doi/10.1083/jcb.201307057 JCB 1219 Correspondence to James L. Salzer: [email protected] Abbreviations used in this paper: -DG, -dystroglycan; MBP, myelin basic protein; mTor, mammalian target of rapamycin; NDRG1, N-myc downstream– regulated gene-1; P0, myelin protein zero; PI 3-K, phosphatidyli...

S: Y.Mikhed, J.R. Hickok, D.D. Thomas. Oxygen regulates nitric oxide mediated signaling by determining the rate of synthesis and metabolism of nitric oxide. (Poster). The 18 National meeting of the Society of Free Radical Biology and Medicine, Atlanta, GA, 2011. PUBLICATIONS: J.R. Hickok, S. Sahni, Y. Mikhed, M.G. Bonini, D.D. Thomas. Nitric oxide suppresses tumor cell migration through N-Myc d...

To identify genes regulated by N-myc, subtraction of whole embryo cDNA was carried out between wild type and N-myc-deficient mutant mice. Six cDNA clones were isolated as representing genes expressed higher in the mutant embryos and two as those expressed lower. One of them, Ndr1, coding for 43 kDa cytoplasmic protein was studied in detail. The Ndr1 gene was augmented 20-fold in the mutant embr...

The interpretation of magnetic field data at low magnetic latitudes is difficult because the vector nature of the magnetic field increases the complexity of anomalies from magnetic rocks. The most obvious approach to this problem is to reduce the data to the magnetic pole, where the presumably vertical magnetization vector will simplify observed anomalies. However, RTP requires special treatmen...

The N-Myc oncoprotein is a critical factor in neuroblastoma tumorigenesis which requires additional mechanisms converting a low-level to a high-level N-Myc expression. N-Myc protein is stabilized when phosphorylated at Serine 62 by phosphorylated ERK protein. Here we describe a novel positive feedback loop whereby N-Myc directly induced the transcription of the class III histone deacetylase SIR...