Nine flavonoid compounds: kaempferol 3-0-beta-(6"-p-coumaroyl)-glucopyranoside, myricetin 3-O-beta-glucopyranoside, quercetin 3-0-beta-glucopyranoside, quercetin 3-0-alpha-rhamnopyranosyl (1-->6)-beta-glucopyranoside, kaempferol 3-0-beta-glucopyranoside, kaempferol 3-0-alpha-rhamnopyranosyl (1-->6)-beta-glucopyranoside, quercetin 7-0-beta-glucoside, quercetin 7-0-beta-diglucoside, kaempferol 7-...

Two new flavonol glycosides, myricetin 4'-O-alpha-L-rhamnopyranoside (1) and quercetin 3'-O-alpha-L-rhamnopyranoside (2), together with a novel biflavonol compound, speciin (3), as well as eleven phenolic metabolites, namely myricitrin (4), europetin 3-O-alpha-L-(1)C(4)-rhamnopyranoside (5), quercitrin (6), hyperin (7), rhamnetin 3-O-beta-galacto-pyranoside (8), caffeic acid (9), caffeic acid m...

Only a few prospective studies have investigated flavonols as risk factors for cancer, none of which has included pancreatic cancer. The latter is usually fatal, rendering knowledge about prevention particularly important. The authors estimated intakes of three flavonols-quercetin, kaempferol, and myricetin-for 183,518 participants in the Multiethnic Cohort Study and examined associations with ...

We tested whether the dominant intestinal sugar transporter GLUT2 was inhibited by intestinal luminal compounds that are inefficiently absorbed and naturally present in foods. Because of their abundance in fruits and vegetables, flavonoids were selected as model compounds. Robust inhibition of glucose and fructose transport by GLUT2 expressed in Xenopus laevis oocytes was produced by the flavon...

BACKGROUND The role of Wnt signalling in carcinogenesis suggests compounds targeting this pathway as potential anti-cancer drugs. Several studies report activation of Wnt signalling in biliary tract cancer (BTC) thus rendering Wnt inhibitory drugs as potential candidates for targeted therapy of this highly chemoresistant disease. METHODS In this study we analysed five compounds with suggested...

Four Chinese pomegranate (Punica granatum L.) cultivars were analyzed for their individual flavonols and flavones (in fruit peel extracts) using High Performance Liquid Chromatography (HPLC), with changes in flavonols and flavones as occurring during fruit development. The results revealed the presence of kaempferol, quercetin, myricetin, luteolin, and apigenin in all the four cultivars. In add...