Hydrogen peroxide-inducible clone-5 (Hic5) is a focal adhesion adaptor protein induced by the pro-fibrotic cytokine, transforming growth factor-β1 (TGF-β1). We have previously demonstrated that TGF-β1 induces myofibroblast differentiation and lung fibrosis by activation of the reactive oxygen species (ROS)-generating enzyme, NADPH oxidase 4 (Nox4). Here, we investigated a potential role for Hic...

153 Effect of Simvastatin on Transforming Growth Factor BETA-1Induced Myofibroblast Differentiation and Collagen Production in Nasal Polyp-Derived Fibroblasts Il-Ho Park, MD, and Heung-man Lee, MD, PhD. Department of otorhinolaryngology-head and neck surgery, Korea university college of medicine, Seoul, South Korea. Background: Statins are the most commonly prescribed drugs for the treatment of...

PURPOSE Recent studies indicate that transforming growth factor (TGF)beta is a potent inducer of corneal myofibroblast differentiation and expression of smooth muscle-specific, alpha-actin (alpha-SMA). Although TGFbeta is known to enhance synthesis of extracellular matrix proteins and receptors, little is known about how it modulates the expression of smooth muscle proteins in nonmuscle cells. ...

Proteinuria is an important cause of tubulointerstitial damage. Anti-proteinuric interventions are not always successful, and residual proteinuria often leads to renal failure. This indicates the need for additional treatment modalities by targeting the harmful downstream consequences of proteinuria. We previously showed that proteinuria triggers renal lymphangiogenesis before the onset of inte...

The vascular adventitia is emerging as an important modulator of vessel remodeling. Adventitial myofibroblasts migrate to the neointima after balloon angioplasty, contributing to restenosis. We postulated that angiotensin II (Ang II) enhances adventitial myofibroblast migration in vitro via reduced nicotinamide-adenine dinucleotide phosphate oxidase-derived H(2)O(2) and that Nox4-based oxidase ...