نتایج جستجو برای: myocarditis heart
تعداد نتایج: 393486 فیلتر نتایج به سال:
Viral myocarditis exhibits different clinical phenotypes depending on the age of the patient. In pediatric patients, viral myocarditis can present as acute heart failure and cardiogenic shock, and in older patients, it often presents as chronic, slowly progressive heart failure and dilated cardiomyopathy. The severity of viral myocarditis is determined by a delicate balance between the viral in...
The angiotensin converting enzyme inhibitor captopril prevents myosin-induced experimental autoimmune myocarditis. Captopril inhibits production of angiotensin II and increases bradykinin signaling, among other actions. To test whether captopril inhibits disease through blockade of angiotensin signaling, we tested the ability of losartan, an angiotensin II receptor blocker, to prevent myosin-in...
Giant cell myocarditis is a serious and frequently fatal inflammatory heart disease of which the etiology remains unknown. In the present study, we investigated the origin of multinucleated giant cells in myocarditis with the use of an experimental model. We also examined the factors relating to the formation of giant cells in myocarditis. Severe myocarditis characterized by the appearance of m...
Th17 cells have been implicated in the pathogenesis of myocarditis. Interleukin (IL)-17A produced by Th17 cells is dispensable for viral myocarditis but essential for the progression to dilated cardiomyopathy (DCM). This study investigated whether the adenoviral transfer of the IL-17 receptor A reduces myocardial remodeling and dysfunction in viral myocarditis leading to DCM. In a mouse model o...
Stegemann (1914) described pathological changes in the myocardium and nervous system of the heart. Siegmund (1931) found inflammation chiefly in the thebesian vessels. Brody and Smith (1936) found pathological changes in the heart of 90 per cent. of the fatal cases. They described three types of myocarditis: 1. Focal or diffuse interstitial myocarditis. 2. Arteritis or periarteritis of the smal...
Mortality due to cardiac cause is common amongst COVID-19 patients. Myocarditis, decompensated heart failure, acute coronary syndrome, sinus tachycardia, atrial fibrillation and right bundle branch block (RBBB) were noted2 in many hospitalized COVID Studies conducted time time, various countries hospitals registered numbers percentages (%) of patients suffering from myocardial injury ranging 8%...
M itral valve stenosis of origin other than rheumatic fever is a rare entity. Giant-cell myocarditis is an extremely rare, with poor prognosis, probably autoimmune, granulomatous disease of the heart. Progressive congestive heart failure, intraventricular conduction defects and ventricular arrhythmias, which in many cases can be fatal, are the usual manifestations of this disease. On the contra...
The comprehension of the pathogenesis of Trypanosoma cruzi-elicited myocarditis is crucial to delineate new therapeutic strategies aiming to ameliorate the inflammation that leads to heart dysfunction, without hampering parasite control. The augmented expression of CCL5/RANTES and CCL3/MIP-1alpha, and their receptor CCR5, in the heart of T. cruzi-infected mice suggests a role for CC-chemokines ...
BACKGROUND Myocarditis is characterized by inflammatory cell infiltration of the heart and subsequent deterioration of cardiac function. Monocytes are the most prominent population of accumulating leucocytes. We investigated whether in vivo administration of nanoparticle-encapsulated siRNA targeting chemokine (C-C motif) receptor 2 (CCR2)-a chemokine receptor crucial for leucocyte migration in ...
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