During the last few years, the myo-inositol-containing phospholipids have elicited considerable interest from biochemists because of their possible dynamic functions in cell membranes. Parallel with this interest in function has been a concerted attack on the problem of elucidating the detailed structures of these complex substances. In general, the more definitive results have come from the la...

Deep dermal wounds induce skin contraction as a result of the traction forcing exerted by (myo)fibroblasts on their immediate environment. These are cells that responsible for regeneration collagen is necessary integrity We consider several mathematical issues regarding models simulate forces (myo)fibroblasts. Since size (e.g. (myo)fibroblasts) much smaller than domain computation, one often co...

Understanding the targeting of KCa3.1 to the basolateral membrane (BLM) of polarized epithelial cells is still emerging. Here, we examined the role of the cytoskeleton (microtubules and microfilaments) and Myosin-Vc (Myo-Vc) in the targeting of KCa3.1 in Fischer rat thyroid epithelial cells. We used a pharmacological approach with immunoblot (for the BLM expression of KCa3.1), Ussing chamber (f...

Amaç: Bu çalışmada, şizofreni ve şizoaffektif bozuklukta medial prefrontal korteks nörokimyasal metabolit düzeylerinin araştırılması amaçlanmıştır. Yöntem: Çalışmaya 15 şizofreni (SCH), 15 şizoaffektif bozukluğu (SAD) olan hasta ve 15 sağlıklı kontrol katıldı. Medial prefrontal korteks (mPFC) N-asetil aspartat (NAA), kreatin içeren bileşikler (Cr), kolin içeren bileşikler (Cho) ve myo-inozitol ...

Myo-inositol participates in various aspects of plant physiology, and myo-inositol oxygenase is the key enzyme of the myo-inositol oxygenation pathway. Previous studies indicated that myo-inositol oxygenase may play a role in plant responses to abiotic stresses. In this study, we focused on the functional characterization of GsMIOX1a, a remarkable alkaline stress-responsive gene of Glycine soja...

The asymmetric desymmetrization of 4,6-diprotected myo-inositol derivatives was achieved by using a bifunctional, readily available nucleophilic catalyst. The orthogonally protected products were obtained in 80-99% yield with 90-99% ee. Such structures serve as potential enantiopure building blocks for the synthesis of myo-inositol phosphates.

‡Department of Biological Sciences, Purdue University, West Lafayette IN 479071-1392, U.S.A. §Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette IN 47907 U.S.A. ¶Present Address: National Institute for Basic Biology, 38 Nishigounaka, Myo-daiji-cho, Okazaki 444-8585, Japan ||Present Address: National Center for Alternative Energy, Environment, and Innovative...