Pyoderma gangrenosum is a rare neutrophilic dermatosis that commonly treated with systemic corticosteroids; however, their potent side effects may warrant tapering, and non-steroidal immunosuppressants help maintain or bolster disease clearance during weaning. Although cyclosporine regarded as favorable corticosteroid-sparing agent, it associated several effects, such renal toxicity hypertensio...

Mycophenolate mofetil (MMF) is an immunosuppressant drug widely used in post-transplant patients and the treatment of various inflammatory conditions. It considered a relatively safe with minimal adverse effects. We managed acute overdose 19 grams (g) MMF suicidal intention 17-year-old female no significant past medical history. Apart from episodes mild headaches, she did not develop other symp...

NSW TAG wishes to thank the following persons who assisted in reviewing this document: Professor Jeremy Chapman (Westmead Hospital), Associate Professor Connie Katelaris (Westmead Hospital), Associate Professor Les Schrieber (Royal North Shore Hospital), Dr Michael Lee (Royal North Shore Hospital), Ms Ceridwen Jones (Royal Prince Alfred Hospital) and Mr Peter Barclay (Westmead Hospital). NSW TA...

OBJECTIVES Definitive sample sizes for clinical trials in rare diseases are usually infeasible. Bayesian methodology can be used to maximise what is learnt from clinical trials in these circumstances. We elicited expert prior opinion for a future Bayesian randomised controlled trial for a rare inflammatory paediatric disease, polyarteritis nodosa (MYPAN, Mycophenolate mofetil for polyarteritis ...

BACKGROUND Polyoma virus-associated nephropathy (PVN) is a common cause of renal transplant failure. The risk factors for the development of PVN have not yet been studied in large cohorts of patients for periods of 20 years. METHODS We collected clinical, renal biopsy and urinary cytology data from all patients with renal transplantations performed at the University Hospital of Basel from 198...

BACKGROUND In recent years an increasing number of cases with polyomavirus (PV)-nephropathy after renal transplantation were reported from several transplant centres. New, highly potent immunosuppressive drugs like tacrolimus or mycophenolate mofetil were accused as risk factors for this increase. However, data about the incidence of PV-nephropathy in correlation to different immunosuppressive ...