The Moran process, as studied by Lieberman, Hauert and Nowak (2005) [1] , is a birth-death process that models the spread of mutations in two-type populations (residents-mutants) whose structure defined digraph. process' central notion probability randomly placed mutant will occupy whole vertex set (fixation probability). We extend this model considering type-specific graphs, consequently prese...

Objective(s): Mutant forms FMS-like tyrosine kinase-3 (FLT3), are reported in 25% of childhood acute lymphoid leukemia (ALL) and 30% of acute myeloid leukemia (AML) patients. In this study, drug response, growth promoting, and protein trafficking of FLT3 wild-type was compared with two active mutants (Internal Tandem Duplication (ITD)) and D835Y. Materials and Methods:FLT3 was expressed on fact...

Increasing environmental temperatures due to climate change adversely affect livestock welfare and health. Moreover, increase the distribution survival of parasites infectious agents. Livestock diseases that cause significant economic losses are a worldwide concern. Toll-like receptor 4 (TLR4) is an ideal marker gene candidate, its critical role it plays in initiating immune response against pa...

Determining the most Tolerant Genotypes of Hashemi Rice Mutant (M3) in Response to Drought Stress using Physiological Growth Indices and Enzymatic Changes

Background: Cell ability to recover from radiation damage is of great relevance in cancer treatment. It is often believed that the inhibition of cell ability to the liquid holding recovery (LHR) may be an indicator of the overall suppression of cell ability to recover from potentially lethal radiation damage. However, the literature contains no experimental evidence whether the LHR inhibition m...

Proteins have unique properties to participate in many structural and physiological processes. Knowledge of the three-dimensional structure proteins is important understand their roles processes functions these Any defect due mutations can cause diseases, treatment unresponsiveness, drug resistance development. The recent emergence new SARS-CoV-2 variants containing that accelerate spread virus...

background :  young chickens are more susceptible to salmonella colonization than older ones that have developed resistance with age as native microflora become established.   methods :  in this study, two groups of fertile eggs were inoculated with 20 cfu of hila or parent strains of s . enteritidis . presence and number of salmonella cells inside the homogenized egg contents were determined on...

Trehalose is a non-reducing sugar that plays an important role in plant growth and development. To study the role of trehalose on lipid metabolism and gluconeogenesis, Arabidopsis thaliana wild type (WT) and TreF (a line expressing trehalase) were grown on ½ MS medium with or without 100 mM sucrose and or trehalose in light or continuous darkness. In dark, trehalose leads skotomorphoge...

In the present study, Streptomyces gulbargensis and its mutant form, S.gulbargensis mu24, immobilized on polyurethane foam were investigated for the production of L-asparaginase using groundnut cake extract as medium. The medium with an initial pH of 8.5 was inoculated with free and immobilized cells separately and then subjected to fermentation by incubation at 40oC and shaking at 200 rev/min....

Tomato (Solanum lycopersicum L.) is an important vegetable crop and acts as model plant for fruit development studies. Besides that, post-harvest damage is a devastating phenomenon often associated with ripening process in tomato which in turn leads to greater yield loss. Understanding the genetics, molecular and biochemical pathways is the key to overcome the existing situation. In th...