In this work, the ethanol fuel dehydration process was optimized using Aspen Plus? simulator and a multivariate statistical technique based on desirability function. The suitability of ionic liquids 1-methylimidazolium chloride ([Mim][Cl]), 1-ethyl-3-methylimidazolium ([Emim][Cl]), 1-butyl- -3-methylimidazolium ([Bmim][Cl]) 1-hexyl-3-methylimidazolium ([Hmim][Cl]), as extractive distillation en...