OBJECTIVES This study investigates the effect of surgical margins and radiotherapy, in the presence of individual baseline characteristics, on survival in a large population of high-grade soft tissue sarcoma of the extremities using a multistate model. DESIGN A retrospective multicentre cohort study. SETTING 4 tertiary referral centres for orthopaedic oncology. PARTICIPANTS 687 patients w...

In this article we present a multistate continuum theory for multiple charge transfer reactions such as proton-coupled electron transfer and multiple proton transfer reactions. The solute is described with a multistate valence bond model, the solvent is represented as a dielectric continuum, and the transferring protons are treated quantum mechanically. This theory provides adiabatic free energ...

The theoretical study in this paper is based on the experimental result that the rate of photoinduced electron transfer is ∼102 times slower through a donor-(amidinium-carboxylate)-acceptor salt bridge than through the corresponding switched interface donor-(carboxylate-amidinium)-acceptor complex (Kirby, J. P.; Roberts, J. A.; Nocera, D. G. J. Am. Chem. Soc. 1997, 119, 9230). This experimental...

Hyperpolarization-activated (pacemaker) channels are dually gated by negative voltage and intracellular cAMP. Kinetics of native cardiac f-channels are not compatible with HH gating, and require closed/open multistate models. We verified that members of the HCN channel family (mHCN1, hHCN2, hHCN4) also have properties not complying with HH gating, such as sigmoidal activation and deactivation, ...

Arizona Station. The Station demonstrated that hepatocyte growth factor (HGF) may be involved in linking mechanical perturbation of muscle to satellite cell activation. Involvement of NO in HGF release and satellite cell activation during stretch was also demonstrated, indicating that stretch triggers an intracellular cascade of events including NO synthesis, resulting in HGF release and satell...

Importance measures in reliability engineering are used to identify weak areas of a system and signify the roles of components in either causing or contributing to proper functioning of the system. Traditional importance measures for multistate systems mainly concern reliability importance of an individual component and seldom consider the utility performance of the system. This paper extends t...

Many real-world systems such as manufacturing systems, transportation systems and logistics/distribution systems that play important roles in our modern society can be regarded as multicommodity flow networks whose arcs have independent, finite and multi-valued random capacities. Such a flow network is a multistate system with multistate components and its reliability for level (d;c), i.e., the...

Recent extensions of occupancy modeling have focused not only on the distribution of species over space, but also on additional state variables (e.g., reproducing or not, with or without disease organisms, relative abundance categories) that provide extra information about occupied sites. These biologist-driven extensions are characterized by ambiguity in both species presence and correct state...

The state of the art in coherent structure theory is driven by two assertions, both of which are limiting: (1) all units of a system can exist in one of two states, failed or functioning; and (2) at any point in time, each unit can exist in only one of the above states. In actuality, units can exist in more than two states, and it is possible that a unit can simultaneously exist in more than on...