conclusions this study showed that ifnβ-1a decreased oxidant impacts in ms patients, but had no influence in improving mitochondrial dysfunction. results in the patients group (30 patients), a significant difference was observed in their measured biochemical factors in comparison to the control group (p = 0.001), however, after six months of using ifnβ-1a, only mda was shown in the main (p = 0....

Multiple sclerosis is an autoimmune disease of the central nervous system characterized by inflammatory demyelination and axonal degeneration. It is the commonest cause of permanent disability in young adults. Environmental and genetic factors have been suggested in its etiology. Currently available disease modifying drugs are only effective in controlling inflammation but not prevention of neu...

the comparison of the effects of effleurage massage with aromatic oil and non aromatic oil on fatigue severity in women with multiple sclerosis bahraini s , naji sa * , mannani r , bekhradi r received: 15june, 2011 accepted: 5september, 2011 abstract background & aims: fatigue is one of the most common signs in multiple sclerosis and also it is one of the common reasons of low quality of life a...

Multiple Sclerosis (MS) is a prevalent neurological and non-traumatic disease which is most common in young and adult women. Multiple Sclerosis is a disabling disease can affect various aspects of life. Studies have reported that complement and alternative treatments can have positive effects on people with MS. Exercise presents an important behavioral approach for counteracting the declines in...

Disease-modifying drugs have mostly failed as treatments for progressive multiple sclerosis. Management of the disease therefore solely aims to minimise symptoms and, if possible, improve function. The degree to which this approach is based on empirical data derived from studies of progressive disease or whether treatment decisions are based on what is known about relapsing-remitting disease re...

Background & Aims: Substance abuse may have different effects on multiple sclerosis. Till now, studies on substance abuse and its correlation with psychopathology, type and severity of multiple sclerosis are limited. We conducted this study to evaluate the psychopathology of patients with multiple sclerosis with and without substance abuse. Methods: In this case-control, cross-sectional study p...

The relevance of tyrosine kinase inhibitors (TKIs) in the treatment of malignancies has been already defined. Aberrant activation of tyrosine kinase signaling pathways has been causally linked not only to cancers but also to other non-oncological diseases. This review concentrates on the novel plausible usage of this group of drugs in neurological disorders, such as ischemic brain stroke, subar...

conclusions the results suggest that the msfc could be used as a simple tool to detect the negative effects of heat in patients with ms. results in the ms group the average msfc scores were -0.48 (sd 0.79) at baseline, -0.99 (sd 1.97) during heat exposure and -0.68 (sd 1.58) after a one-hour delay. the average msfc scores of the hc group were 0.58 (sd 0.42) at baseline, 0.66 (sd 0.43) during he...