multiple sclerosis (ms) is a complex disease which is correlated with increasing inflammatory factors, demyelination and axonal loss. in this auto-immune disease, neuroinflammation is mediated by different types of t cells with macrophage/microglial activation and b cells involvement that interact in a collaborative manner. focal inflammation is the main cause for the onset of relapses and coul...

soluble forms of nonclassical human leukocyte antigen (hla)-g have recently been suggested as immunomodulatory factors in multiple sclerosis (ms). hla-g inhibits the effecter function of t cells and natural killer (nk) cells. also regulatory t cells (treg) are considered as pivotal players in ms pathogenesis. thus, we aimed to evaluate the presence of hla-g molecules and treg cells in relapsing...

multiple sclerosis (ms) is a demyelinating disease of the central nervous system, with unknown etiology in which both genetic and environmental factors are thought to be involved. the human leukocyte antigen (hla) system provides a set of genetic markers which lend themselves to systematic study. in iran, hla-a24, hla-dr2, and hla- dr15 are significantly increased in ms patients. the disease al...

background: multiple sclerosis (ms) is a demyelinating disease of the central nervous system and cytokines may play a role in the development of ms lesions. objective: to determine levels of different cytokines in patients with relapsing-remitting ms (rr-ms) compared to healthy controls. methods: profiles of pro-inflammatory, th1-, th2-, and th17-related cytokines were compared by quantitative ...

background: lack of sufficient information on the mechanism of plasma exchange (pe) therapy in multiple sclerosis (ms), has limited this treatment to individual patients with severe relapses who have been refractory to other treatments. this is while pe is used very successfully as a first-line standard treatment in many other neuro-immune disorders. recent data suggest that treg/th17 counterba...

Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system (CNS). This highlydisabling disorder is characterized by a variable clinical course. MS is a heterogeneous disease with acomplex pathology and significant social and economic impact. MS is associated with dysfunction ofparts of the nervous system which results in a range of signs and symptoms, ...

objective(s): regulatory t cells, including cd4+cd25+fox3+ and cd8+cd28- cells play an important role in regulating the balance between immunity and tolerance. since multiple sclerosis is an inflammatory autoimmune disease, regulatory t cells are considered to be involved in its pathogenesis. in this study, we investigated the circulatory numbers of the two mentioned types of regulatory t cells...

how to cite this article: naser moghaddasi a. neuroplasticity in early onset multiple sclerosis. iran j child neurol. 2014autumn;8(4): 80-81.   letter to editor, has not abstract. references boiko a, vorobeychik g, paty d, devonshire v, sadovnick d; neurologists. early onset multiple sclerosis: a longitudinal study. neurology 2002; 59(7):1006-10. inaloo s, haghbin s. multiple sclerosis in child...

background: pain, a common phenomenon in multiple sclerosis (ms) patients, is associated with many symptoms and problems.  to investigation severity and distribution of musculoskeletal pain in ms patients. methods: in this cross-sectional study, 115 members of the mazandaran ms association with confirmed ms were randomly selected to participate in the study. the patients were asked to fill out ...

background multiple sclerosis (ms) is an autoimmune disease that affects the central nervous system (cns). ms is one of the most common cause of neurological impairment at a young age with a complex etiology. the forkhead/winged helix (foxp3) gene encodes a transcription factor that plays an important role in the working and progress of regulatory t cells. loss of the foxp3 function impairs the...