autoimmune diseases have been described as an interesting and poorly understood group of disorders. there are many challenges in the respective scientific societies concerning the nature, causes and the therapeutic approaches of these diseases. in accordance with the evidences the nature and etiology of these disorders is multifactorial and complex but the clearest definition could be expressed...

multiple sclerosis is an autoimmune disease caused by damage to the myelin of the nerve cells in the spinal cord and brain, ms was classified into 4 types including: relasping/remitting (rr) primary/progressive (pp), secondary/progressive (sp), progressive/relapsing (pr). pr ms is one of the severe forms of ms that lead to inflammation associated physical, mental and vision dysfunction. because...

noncoding ribonucleic acids micro-rna is involved in the regulation of gene expression have major roles in the post-transcriptional level. a micro-rna alone several causes down regulation of mrna transcript of the target. thus, small changes in the expression of a micro rna may lead to significant changes in gene expression are different. micro- rna as key regulators of immune cell lineage diff...

multiple sclerosis is an autoimmune disease of the central nervous system which its main characteristic is an inflammation and demyelination and subsequent, neural degeneration. many studies have shown that inflammation causing neuronal demyelination. ms is the most common cause of chronic neurological disability in during youth which the prognosis is that can be death. platelet activating fact...

guillain-barre syndrome (gbs) or acute idiopathic polyradiculoneuritis is an acquired immune-mediated inflammatory and mainly demyelinating disorder of the peripheral nervous system. cranial nerves are affected in over 50% of all cases, with the facial nerves being affected the most. it uncommonly presents as atypical forms such as brachial pharyngeal variant, miller fisher and other restricted...

background: initial symptoms of multiple sclerosis (ms) may be varied and nonspecific. we tried to find the frequency distribution of the first clinical symptoms in iranian patients with ms. methods: in a case series study, 1130 patients with definite diagnosis of ms who had been referred to three referral university hospitals of tehran, iran, were enrolled. the patients' medical records were r...

conclusions the current study adds evidence to the association of tnf-α gene polymorphism and ms in this southern south iranian population which is consistent with the genetic analysis of ms in europeans (games) project reports and these two alleles reported in this study may be one of the genetic risk factor for ms. furthermore, this data can be used to build the iranian gene bank for future s...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 background: the efficacy of mitoxantrone induction therapy in rapidly worsening multiple sclerosis (ms) is well established. plasma exchange is also applied as an adjuvant in exacerbations of relapsing ms. the aim of this study was to compare the efficacy of combination therapy with mitoxantrone and plasma exchange versus ...

background: sexual dysfunction (sd) is a common reported problem in patients with multiple sclerosis (ms). aims: to examine frequency and distribution of sd dimensions and to determine whether sd is related to various clinical and demographic variables in female patients. materials and methods: a total of 271 ms women (age: 19-50 years) participated in this cross-sectional study. we used a stru...

conclusions implementing the self-management program plus regular follow-up increased the perception of self-efficacy in patients with ms. similar self-management programs are recommended to be integrated in the regular caring of patients with ms. results no significant difference in mean scores of baseline self-efficacy was found between the control (52.90 ± 8.03) and the intervention groups (...