PURPOSE To correlate the phenotype of four patients with inherited macular disease with the immunohistopathology of retinal tissue collected at the time of retinal pigment epithelium (RPE)-choroidal transplantation. METHODS A clinicopathologic case series describing the phenotype of four patients, including confocal immunohistochemistry and electron microscopy (EM), and the results of genetic...

PURPOSE To evaluate macular function, before and after photodynamic therapy (PDT) using multifocal electroretinogram (MF-ERG), in eyes suffering from classic subfoveal choroidal neovascularization (CNV) resulting from age-related macular degeneration (ARMD). METHODS Twenty eyes of 20 patients (10 male, 10 female) with classic subfoveal CNV resulting from ARMD were studied. All received PDT wi...

Our aim was to determine whether patients with retinitis pigmentosa show differences in L- and M-cone multifocal visual evoked potential (mfVEP) responses that are eccentricity dependent, as has been shown for control subjects. Second, we compared the losses for mfVEPs to losses on achromatic visual field and multifocal electroretinogram (mfERG) measures in the patients. Monocular mfVEPs were r...

OBJECTIVE The use of the multifocal pattern electroretinogram (mfPERG) for objective visual field testing is critically impaired by the small signal-to-noise ratios (SNRs) obtained. In order to explore ways to enhance mfPERG-SNRs and mfPERG-magnitude, the dependence of mfPERGs and multifocal visual evoked potentials (mfVEPs) on stimulation rate and stimulation mode is examined. METHODS Using ...