Multidrug resistance is a potent barrier to effective, long term therapy in cancer patients. It is frequently attributed to enhanced expression of multidrug transporters or to the action of receptor kinases, such as ErbB2, and downstream anti-apoptotic signaling pathways, such as the phosphoinositide 3-kinase/Akt pathway. However, very few connections have been made between receptor kinases or ...

Considering the possibility to overcome drug resistance by other treatment strategies than chemotherapy we investigated the susceptibility of three independently selected multidrug-resistant sublines of the T-lymphoblastoid leukemic cell line CCRF-CEM to lymphokine-activated killer (LAK) cells. We found that two of the multidrug-resistant sublines were significantly less susceptible targets to ...

objective(s): acquisition of tnf-α resistance plays role in the onset and growth of malignant tumors. previous studies have demonstrated that mcf-7 cell line and its doxorubicin resistant variant mcf-7/adr are resistant against the cytotoxic effects of tnf-α. in this study, we investigated the role of akt activation in resistance of mcf-7 and mcf-7/adr against tnf-α cytotoxicity. materials and ...

conclusions the result of the current study showed the growing number of nosocomial infections associated with xdr a. baumannii causing difficulties in antibiotic therapy. resistant strains increasingly cause public health problems; therefore, their early detection is essential for healthcare centers. results among the 121 isolated a. baumannii, 44% and 56% were isolated from female and male, r...

several transporters appear to be important in transporting various drugs. many patients, who receive morphine as analgesic medication, also receive other medications with potency of changing morphine transport by affecting p-glycoprotein (p-gp) and oatp2 transport system. this could influence morphine pharmacokinetics and pharmacodynamics. the aim of present study was to elucidate the transpor...

background: lower respiratory tract infections are among important causes of morbidity and mortality for all age groups. the emergence of multidrug resistant gram-negative bacilli is an issue of increasing concern. materials and methods: a retrospective study including respiratory specimens (sputum and bal) was conducted in our tertiary care centre. samples were processed for microscopy, cultur...

objective(s): p-glycoprotein (p-gp) is an efflux protein, the overexpression of which has been associated with multidrug resistance in various cancers. although sirna delivery to reverse p-gp expression may be promising for sensitizing of tumor cells to cytotoxic drugs, the therapeutic use of sirna requires effective carriers that can deliver sirna intracellularly with minimal toxicity on targe...

conclusions this blis with broad-spectrum activity may be a potential agent for the treatment or control of drug-resistant strains of p. aeruginosa infection. results among the 96 isolates of p. aeruginosa, 2 (2.1%), 94 (97.9%), and 63 (65.6%) were non-mdr, mdr, and xdr, respectively, and 1 (1.1%) was pdr. the most effective antibiotics against these isolates were polymyxins and fosfomycin. a b...

conclusions: this study highlighted the need to establish antimicrobial resistance surveillance networks for p. aeruginosa to determine the appropriate empirical treatment regimens. the high prevalence of multidrug resistance and production of esbls in p. aeruginosa isolates confirms the necessity of protocols considering these issues in the hospitals. results: the resistance against broad-spect...