It is an exciting time for all those engaged in the treatment of colorectal cancer. The advent of new therapies presents the opportunity for a personalized approach to the patient. This approach considers the complex genetic mechanisms involved in tumorigenesis in addition to classical clinicopathological staging. The potential predictive and prognostic biomarkers which have stemmed from the st...

The placenta is a unique organ with dual blood circulation, functioning throughout foetal development. Placental trophoblasts express and produce coagulation components, participating not only in haemostasis but also in placental vascular development and differentiation1. The earlier insight into this organ comes from drawing from illustrators such as Andreas Vesalius (1514-1564). The designati...

We review recent determinations of the Boltzmann constant kB and differences T − T90 that used cylindrical acoustic gas thermometry (c-AGT). These measured resonance frequencies argon enclosed by metal-walled, cavities. (Here, is thermodynamic temperature on International Temperature Scale 1990, ITS-90.) In range 234–303 K, standard uncertainty c-AGT ranges from 1.9 × 10−6T to 2.6 10−6T. This m...

The wheat stem sawfly, Cephus cinctus Norton (Hymenoptera: Cephidae), is a major pest of (Triticum aestivum L.) in the northern Great Plains, where it constant threat Montana and resurging Alberta, Saskatchewan, North Dakota. Adoption solid-stemmed cultivars an important management tool for growers; however, inconsistent pith expression first noted with release ‘Rescue’ has been repeatedly obse...

In recent years, some people, comparing the word “Ahmad” in a Quranic verse speaking of Jesus’ prophecy about Prophet Muhammad (Qur'an 61:6) with the word “Paraclete” in the Gospel of John (14:26, etc.), have tried to make a connection between them. They have ascribed to Muslims (and even to the Prophet himself) the idea that the word “Paraclete” is a distorted form of the word “periclete</...

Palliative care in the UK has been ranked as the best in the world. However, the Liverpool Care Pathway was criticised and phased out. This article looks at the LCP's aims, assesses the problems and how these should be tackled. Many of these problems stemmed not from the LCP itself, but its improper use. Better training on the pathway and on communication with patients and relatives could ensur...