Ras proteins are post-translationally modified by farnesylation. In the present investigation, we identified an activity in crude soluble extracts of yeast cells that catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to yeast RAS2 protein. RAS2 proteins having a C-terminal Cys-Ali-Ali-Xaa sequence (where Ali is an aliphatic amino acid and Xaa is the unspecified C-terminal ...

The independent effects of chronic disease, age, severity of illness, lung injury score (LIS) and etiology, and preceding nonpulmonary organ-system dysfunction (OSD) on the outcome of acute lung injury (ALI) have not been examined in an exclusively medical-intensive-care-unit (MICU) population. Therefore, 107 consecutive MICU patients with ALI (76% with acute respiratory distress syndrome [ARDS...

Ziele. Mit dem Projekt „ali – Aachener eLeitprogramme der Informatik“ verfolgen wir mehrere Ziele, die dazu beitragen sollen, Lehrkräften gute Unterrichtsbeispiele zur Verfügung zu stellen und die Arbeitsweise einer „fremden“ Unterrichtsvorbereitung sowie den Einsatz digitaler Medien zu etablieren. Zum einen sollen aktuelle Unterrichtsinhalte der Informatik mit konkret ausgearbeiteten Beispiele...

BACKGROUND/AIMS Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a serious health problem, and an effective treatment is needed for use in the clinical setting. METHODS In this study, we first constructed ALI models in Adult Sprague-Dawley rats. We then used an herbal medicine, Houttuynia cordata (HC), to enhance the effect of endothelial progenitor cells (EPCs) on ALI. R...

Optimization of intratracheal instillation is necessary to establish an ideal animal model of acute lung injury (ALI) in order to further reveal the cellular and molecular pathogenesis of ALI. It is possible that instilling air from a prefilled syringe may promote the delivery of reagents into the alveolar spaces, resulting in different pulmonary responses. In the present study, the influence o...

The Allostatic Load Index (ALI) has been used to establish associations between stress and health-related outcomes. This review summarizes the measurement and methodological challenges of allostatic load in occupational settings. Databases of Medline, PubPsych, and Cochrane were searched to systematically explore studies measuring ALI in working adults following the PRISMA statement. Study char...

Acute lung injury (ALI) and its more severe form, the acute respiratory distress syndrome (ARDS), are syndromes of acute respiratory failure that result from acute pulmonary edema and inflammation. The development of ALI/ARDS is associated with several clinical disorders including direct pulmonary injury from pneumonia and aspiration as well as indirect pulmonary injury from trauma, sepsis, and...

UNLABELLED Enteral immunomodulatory nutrition is considered as a promising therapy for the treatment of acute lung injury and acute respiratory distress syndrome (ALI/ARDS). However, there are still some divergences, and it is unclear whether this treatment should be recommended for patients with ALI/ARDS. Therefore, we conducted this systematic review and meta-analysis to assess the efficacy a...

Bu araştırmada Osmanlı Devleti’nin Gerileme dönemi içinde olan 1788 – 1821 yılları arasında Yanya Valisi olarak görev yapan Tepedelenli Ali Paşa’nın üç romandaki tezahürü incelenir. Bunlar, Ahmet Mithat Efendi’nin Arnavutlar Solyotlar, İsmail Kadare’nin İbret Taşı (Kamarja e Turpit) ve Alexandre Dumas’ın Paşa (Ali Pacha) adlı romanlarıdır. Bahsi geçen tarihî şahsiyetin sırasıyla Türk, Arnavut F...

This paper compares the performance of keyword and machine learning-based chest x-ray report classification for Acute Lung Injury (ALI). ALI mortality is approximately 30 percent. High mortality is, in part, a consequence of delayed manual chest x-ray classification. An automated system could reduce the time to recognize ALI and lead to reductions in mortality. For our study, 96 and 857 chest x...