نتایج جستجو برای: mtd
تعداد نتایج: 1531 فیلتر نتایج به سال:
Architecture-Based Self-Adaptation for Moving Target Defense Report Title The fundamental premise behind Moving Target Defense (MTD) is to create a dynamic and shifting system that is more difficult to attack than a static system because a constantly changing attack surface at least reduces the chance of an attacker finding and exploiting the weakness. However, MTD approaches are typically chos...
The rate of observed dose-limiting toxicities (DLT) determines the maximum tolerated dose (MTD) in phase I trials. There are cases in which non-drug-related toxicities or other-cause toxicities (OCT) are flagged as DLTs, or vice versa, due to attribution errors. We aim to assess the impact of such errors on the final estimate of MTD. We compared the impact of attribution errors using 2 trial de...
PURPOSE In preclinical models, calcitriol and the tyrosine kinase inhibitor gefitinib are synergistic and modulate extracellular signal-regulated kinase (Erk) and Akt pathways. Therefore, we conducted a phase I study of calcitriol and gefitinib to determine the maximum tolerated dose (MTD) of this combination. EXPERIMENTAL DESIGN Calcitriol was given i.v. over 1 h on weeks 1, 3, and weekly th...
To develop allopregnanolone as a therapeutic for Alzheimer's disease, we investigated multiple formulations and routes of administration in translationally relevant animal models of both sexes. Subcutaneous, topical (transdermal and intranasal), intramuscular, and intravenous allopregnanolone were bolus-administered. Pharmacokinetic analyses of intravenous allopregnanolone in rabbit and mouse i...
A large area (128m) Muon Tracking Detector (MTD), located within the KASCADE experiment, has been built with the aim to identify muons (Eμ >0.8GeV) and their directions in extensive air showers by track measurements under more than 18 r.l. shielding. The orientation of the muon track with respect to the shower axis is expressed in terms of the radialand tangential angles. By means of triangulat...
In this paper we describe an empirical study of human-human multi-tasking dialogues (MTD), where people perform multiple verbal tasks overlapped in time. We examined how conversants switch from the ongoing task to a real-time task. We found that 1) conversants use discourse markers and prosodic cues to signal task switching, similar to how they signal topic shifts in single-tasking speech; 2) c...
PURPOSE To determine the maximum-tolerated dose (MTD), toxicities, and clinical effect of tipifarnib, a farnesyltransferase (FTase) inhibitor, in patients with recurrent malignant glioma taking enzyme-inducing antiepileptic drugs (EIAEDs). This study compares the pharmacokinetics and pharmacodynamics of tipifarnib at MTD in patients on and off EIAEDs. PATIENTS AND METHODS Recurrent malignant ...
The third issue of the fourth volume of the EAI transactions on Security and Safety provides an insight to methods and techniques that improve security, resiliency and privacy of modern systems, such as clouds, moving target defense (MTD)-enabled systems and Blockchains. The articles that constitute this issue focus on three main areas. The first one consists of novel methods that can increase ...
MicroRNA (miRNA) mediates RNA interference to regulate a variety of innate immune processes, but how miRNAs coordinate the mechanisms underlying acute lung injury/acute respiratory distress syndrome (ALI/ARDS) in patients with pulmonary inflammatory injury is still unknown. In this study, we demonstrated that miR-223 limits the number of Ly6G+ neutrophils and inhibits the activity of the NLRP3 ...
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