BACKGROUND Fingolimod efficiently reduces multiple sclerosis (MS) relapse by inhibiting lymphocyte egress from lymph nodes through down-modulation of sphingosine 1-phosphate (S1P) receptors. We aimed to clarify the alterations in peripheral blood T cell subsets associated with MS relapse on fingolimod. METHODS/PRINCIPAL FINDINGS Blood samples successively collected from 23 relapsing-remitting...

OBJECTIVES The present work was designed to test the effects of amiodarone therapy on action potential characteristics of the three cell types observed in human left ventricular preparations. BACKGROUND The electrophysiologic basis for amiodarone's exceptional antiarrhythmic efficacy and low proarrhythmic profile remains unclear. METHODS We used standard microelectrode techniques to investi...

Despite many years of intensive research, multiple sclerosis (MS) defies understanding and treatment remains suboptimal. The prevailing hypothesis is that MS is immune mediated and that experimental allergic encephalomyelitis (EAE) is a suitable model to elucidate pathogenesis and devise therapy. This review examines critically the validity that EAE is an adequate and useful animal model of MS ...

Low dose naltrexone (LDN) has become a popular off-label therapy for multiple sclerosis (MS). A few small, randomized studies indicate that LDN may have beneficial effects in MS and other autoimmune diseases. If proven efficacious, it would be a cheap and safe alternative to the expensive treatments currently recommended for MS. We investigated whether a sudden increase in LDN use in Norway in ...

BACKGROUND Changes in autonomic cardiac function are frequent during menopause, and various methods have been used to understand and minimize them. OBJECTIVE To study the interference of dynamic aerobic physical activity on heart rate variability (HRV) in climacteric women. METHODS Cross-sectional study that analyzed HRV in 15 menopausal women (mean age 56.8+/-4.9 years) who had participate...

The purpose of this study was to quantify the changes of tumor blood flow (BF) in cervical cancer after radiation therapy by using perfusion computed tomography (CT), and to examine the difference between maximum slope (MS) and single-input one-compartment model (SOCM) methods. Fourteen consecutive patients who received definitive radiation therapy for cervical cancer from October 2009 to Febru...

neuroinflammation is a disorder that causes neurological disease. neuroinflammation has a significant role in induce of multiple sclerosis (ms) and one of the situations that must be treated stops the ongoing process of inflammation against the cns by self-reactive lymphocytes. according to the successful results that were obtained from the pre-clinical phase of cell therapy, many studies were ...

BACKGROUND Atrioventricular (AV) node ablation and pacing has become accepted therapy for drug-refractory paroxysmal atrial fibrillation (PAF). However, few data demonstrate its superiority over continued medical therapy. The influence of pacing mode and mode-switch algorithm has not been investigated. METHODS AND RESULTS Symptomatic patients who had tried >/=2 drugs for PAF were randomized t...

OBJECTIVES The objective of the present study was to compare the efficacy of cefuroxime with that of dicloxacillin as definitive antimicrobial therapy in methicillin-susceptible Staphylococcus aureus bacteraemia (MS-SAB) using a Danish bacteraemia database, information on the indication for antimicrobial therapy, multivariate adjustment and propensity score (PS) matching. METHODS This was a r...

Abstract Background The incidence of thyroid dysfunction in multiple sclerosis (MS) patients on interferon (as a disease-modifying line) has been reported many studies performed already therapy. Our study adopted prospective follow-up the profile those newly starting beta therapy over 1 year trying to find correlation between start and occurrence this dysfunction. Objectives To evaluate MS befo...