نتایج جستجو برای: mrm
تعداد نتایج: 1660 فیلتر نتایج به سال:
BACKGROUND AND PURPOSE The laminar patterns displayed by MR microscopy (MRM) form one basis for the classification of the cytoarchitectonic areas (Brodmann areas). It is plausible that in the future MRM may depict Brodmann areas directly, and not only by inference from gross anatomic location. Our purpose was to depict the laminar cytoarchitecture of excised, formalin-fixed specimens of human c...
BACKGROUND If liquid-chromatography-multiple-reaction-monitoring mass spectrometry (LC-MRM/MS) could be used in the large-scale preclinical verification of putative biomarkers, it would obviate the need for the development of expensive immunoassays. In addition, the translation of novel biomarkers to clinical use would be accelerated if the assays used in preclinical studies were the same as th...
There is an increasing need in biology and clinical medicine to robustly and reliably measure tens to hundreds of peptides and proteins in clinical and biological samples with high sensitivity, specificity, reproducibility, and repeatability. Previously, we demonstrated that LC-MRM-MS with isotope dilution has suitable performance for quantitative measurements of small numbers of relatively abu...
Background Iterative self-consistent parallel imaging (PI) reconstruction (SPIRiT) [1, Lustig M, MRM 64:457-71,2010] has been extended for dynamic imaging by exploiting temporal correlations in k-t space (k-t SPIRiT) [2,Santelli C, MRM 72:1233-45, 2014]. Using eigendecomposition of a modified SPIRiT operator, computationally optimized reconstruction formally translates into auto-calibrated SENS...
BACKGROUND The optimal combination of anesthetic agent and technique may have an influence on long-term outcomes in cancer surgery. In vitro and in vivo studies suggest that propofol independently reduces migration of cancer cells and metastasis. Thus, the authors retrospectively examined the link between propofol-based total intravenous anesthesia (TIVA) and recurrence or overall survival in p...
PURPOSE The aim of this study was to quantify specific proteins deposited on daily wear silicone hydrogel lenses used in combination with multipurpose disinfecting solutions (MPDSs) by applying multiple-reaction-monitoring mass spectrometry (MRM-MS). METHODS Balafilcon A or senofilcon A contact lenses used with different MPDSs on a daily wear schedule were collected. Each worn lens was extrac...
Multiple Reaction Monitoring (MRM), also known as Selected Reaction Monitoring (SRM), is a powerful targeted proteomics method. The approach is based on the generation of specific quantitative assays for each protein of interest and can be used to accurately quantitate large sets of proteins at high throughput. One challenge in Multiple Reaction Monitoring Proteomics analysis is however to sele...
In many studies, particularly in the field of systems biology, it is essential that identical protein sets are precisely quantified in multiple samples such as those representing differentially perturbed cell states. The high degree of reproducibility required for such experiments has not been achieved by classical mass spectrometry-based proteomics methods. In this study we describe the implem...
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