BACKGROUND MR-guided focused ultrasound (MRgFUS) might be a very safe and effective minimally invasive technique to treat facet joint pain caused by arthritis and other degenerative changes. However, there are still safety concerns for this treatment and challenges regarding MR imaging and temperature mapping due to susceptibility effects between the bone and soft tissue near the joint, which h...

OBJECTIVE The aim of this study was to determine if the noninvasive or minimally invasive and nondestructive imaging techniques of quantitative T2-mapping or multiphoton microscopy (MPM) respectively, could detect differences in cartilage collagen orientation similar to polarized light microscopy (PLM). It was hypothesized that MRI, MPM, and PLM would all detect quantitative differences between...

In proton magnetic resonance (MR) spectroscopy (1H-MRS) of the breast cancer, choline peak could be detected. The purpose this study was to evaluate influences tumor volume, full width at half maximum (FWHM) water (FWHM), and T2* value (T2* value) on detection rate peaks 3.0 T-MRI. We measured FWHM in 109 cases, we evaluated effect volume peaks. 1H-MRS cancer T-MRI, improved as larger. As a shi...

The work of Ricardo Cury et al1 published this week in Circulation uses T2-weighted magnetic resonance imaging (MRI) to detect recent myocardial ischemia on the basis of subtle differences in myocardial water characteristics. They found that T2-weighted MRI improved diagnostic accuracy when characterizing patients with possible or probable acute coronary syndrome (ACS) who presented to the emer...

MRI is routinely used for in vivo detection of multiple sclerosis (MS) lesions. Histopathological correlates of MRI signal alterations are still poorly defined. In the present study, we describe a mouse model of MS presenting with inflammatory brain lesions. During the acute disease phase, two independent lesion patterns were identified by T1- and T2-weighted high-resolution 3D MRI: lesions wit...

BACKGROUND Transfusional therapy for thalassemia major and sickle cell disease can lead to iron deposition and damage to the heart, liver, and endocrine organs. Iron causes the MRI parameters T1, T2, and T2* to shorten in these organs, which creates a potential mechanism for iron quantification. However, because of the danger and variability of cardiac biopsy, tissue validation of cardiac iron ...