Published articles have been reprinted with the permission of the copyright holder. Abstract ABSTRACT The studies presented here evaluate the biliary, parenchymal and vascular enhancement effects of two T1-shortening liver-specific contrast agents, Gd-BOPTA and Gd-EOB-DTPA, in Magnetic Resonance Imaging (MRI) of healthy subjects and of patients. Ten healthy volunteers were examined with both co...

Introduction Ultra-short, single-walled carbon nanotube capsules internalized with paramagnetic gadolinium-ion clusters (Gadonanotubes), see Figure 1, possess the unusual ability to cause marked shortening of both T1 and T2 (1,2). In this work we report the magnetic properties of the Gadonanotubes that underlie the significantly shortened T1 and T2 * relaxation times. Thus, the Gadonanotubes re...

A dual probe with fluorescent and magnetic reporter groups was constructed by linkage of the near-infrared (NIR) fluorescent transferrin conjugate (Tf(NIR)) on the surface of contrast agent-encapsulated cationic liposome (Lip-CA). This probe was used for magnetic resonance imaging (MRI) and optical imaging of MDA-MB-231-luc breast cancer cells grown as a monolayer in vitro and as solid tumor xe...

Human and murine cerebral malaria are associated with elevated levels of cytokines in the brain and adherence of platelets to the microvasculature. Here we demonstrated that the accumulation of platelets in the brain microvasculature can be detected with MRI, using what we believe to be a novel contrast agent, at a time when the pathology is undetectable by conventional MRI. Ligand-induced bind...

Ferumoxytol is an ultrasmall superparamagnetic iron oxide (USPIO) agent initially approved by the Food and Drug Administration (FDA) as an iron replacement therapy for patients with anemia due to chronic renal failure. Recently, ferumoxytol has been investigated extensively as an intravenous contrast agent in magnetic resonance imaging (MRI). Since it causes regional T1 and T2 * shortening in v...

Accurate diagnosis in early stage is vital for the treatment of Hepatocellular carcinoma. The aim of this study was to investigate the potential of poly lactic acid-polyethylene glycol/gadolinium-diethylenetriamine-pentaacetic acid (PLA-PEG/Gd-DTPA) nanocomplexes using as biocompatible molecular magnetic resonance imaging (MRI) contrast agent. The PLA-PEG/Gd-DTPA nanocomplexes were obtained usi...

An intelligent MRI contrast agent has been designed by taking advantage of a microenvironmental responsive polyion complex (PIC). The intelligent signal switching was achieved by controlling Gd ion-water interactions in the microenvironmental responsive PIC. MRI signal of the agent appeared only in tumor region, selectively, and did not appear in normal tissues, when the agent was administrated...