BACKGROUND Multiple cellular functions are compromised in amyotrophic lateral sclerosis (ALS). In familial ALS (FALS) with Cu/Zn superoxide dismutase (SOD1) mutations, the mechanisms by which the mutation in SOD1 leads to such a wide range of abnormalities remains elusive. METHODOLOGY/PRINCIPAL FINDINGS To investigate underlying cellular conditions caused by the SOD1 mutation, we explored mut...

The present study investigated the development of crown and bridge resin using a new PNC-EMA monomer. M MA monomer has long been used for crown and bridge resins, but the polymer prepared with MMA monomer has certain demerits such as low mechanical strength and abrasion resistance. The authors prepared a polymer by mixing 3PNC-EMA monomer having a P=N bond in its skeleton, previously synthesize...

-Gradient elution in nonlinear chromatography is a very powerful tool for the separation of components having a wide range of retentivity. It is not only used for chemical analysis, but also used in preparativeand large-scale chromatography for the separation of many macromolecules, such as proteins. In this work, a general rate model has been presented for the study of gradient elution in nonl...

A series of new polyamides containing maleimide pendant group were prepared by low temperature polycondensation of 5-(4-(2,5-dioxo-2H-pyrrol-1(5H)-yl)benzamido)isophthaloyl chloride as a new monomer with various aromatic diamines in NMP. Monomer and polymers structures were identified through FT-IR, 1H-NMR and elemental analysis. Obtained polymers were soluble in polar solvents and non solu...

A novel acrylate monomer containing 4H-pyran-4-one and 1,2,3-triazole ring, {1-[4-(4-oxo-6-phenyl-4H-pyran-2-yl)benzyl]-1,2,3-triazol-4-yl}methyl acrylate was synthesized by the reaction of 2-{4-[(4-(hydroxymethyl)-1,2,3-triazol-1-yl)methyl]phenyl}-6-phenyl-4H-pyran-4-one with acryloyl chloride in the presence of triethylamine. The structure of the acrylate monomer was established on the basis ...

Determination of antibody avidity measurements can be difficult in human serum depending on the population evaluated. We evaluated three approaches for the determination of antibody avidity for immunoglobulin G (IgG). These approaches were (i) elution of bound antibody with increasing concentrations of a chaotropic agent using a single serum dilution, (ii) binding interference of multiple serum...

In hair fiber, a cysteine-rich calcium-binding S100A3 protein is segregated in the inner part of the cuticle and postulated to play an important role in the attachment o the adjacent cuticular scale. In this study, elution of S100A3 from hair fiber was examined under various conditions by means of immunoblot analyses. The exposure of hair fiber to permanent waving lotions resulted in recoveries...