Biocatalytic acylation/amidation is well-known and has been applied for decades but it has often been limited to the use of organic solvents to avoid hydrolysis. The acyl transferase from Mycobacterium smegmatis (MsAcT) is an enzyme that can perform trans-acylations in aqueous solution. Only a few hydrolases can catalyze trans-acylation in water and MsAcT also has the ability to act as a perhyd...

Abstract The synthesis and structural characterization of N -(6-methoxypyridin-3-yl)-4-(pyridin-2-yl)thiazol-2-amine mono-hydrobromide monohydrate ( 3 ) -(6-methoxypyridin-3-yl)-4-(pyrazin-2-yl)thiazol-2-amine 0.35 methanol solvate 4 are reported. crystal structures (monoclinic, space group P 2 1 / n , Z = 4) group, C 2/ c 8) feature ,4-diheteroaryl 2-aminothiazoles showing similar molecular co...

An efficient and facile synthetic procedure has been developed for the synthesis of novel series Bis-6-aryl-imidazo[1,2-a]pyridine-2-carboxamide containing 3,3'-((oxybis(ethane-2,1-diyl))bis(oxy))bis(propan-1-amine) derivatives (6a-6j). application Palladium catalyzed Suzuki reaction on amine-(CH2)3-PEG3-(CH2)3-amine linked 6-bromo imidazo[1,2-a]pyridine-2-carboxamide was reported their product...

The title complex, [Cd(C(6)H(17)N(3))(2)](ClO(4))(NO(3)), was synthesized by the reaction of Cd(NO(3))(2)·4H(2)O, bis-(3-amino-prop-yl)-amine and sodium perchlorate in methanol. The asymmetric unit of the title complex consists of one Cd(2+) cation, two tridentate bis-(3-amino-prop-yl)amine ligands, one nitrate anion and one perchlorate anion. The Cd(2+) cation is coordinated by six N atoms of ...

The formation of gold nanoparticle–lipid composite films by glucose-induced reduction of chloroaurate ions entrapped in thermally evaporated fatty amine films is described. Simple immersion of films of the salt of octadecylamine and chloroaurate ions (formed by immersion of thermally evaporated fatty amine films in chloroauric acid solution) in glucose solution leads to the facile in-situ reduc...

The carcinogenicity of five derivatives of nitrosodiethylamine was compared with that of the parent compound by p.o. administration to rats. All were less potent than was nitrosodiethylamine. When nitrosobis(2-methoxyethyl)amine and nitrosobis(2-ethoxyethyl)amine were administered at equimolar doses in drinking water, there was a high incidence of liver tumors, but the animals died later than t...

to develop a new more accurate spectrophotometric method for detecting monoamine oxidase inhibitors from plant extracts, a series of amine substrates were selected and their ability to be oxidized by monoamine oxidase was evaluated by the hplc method and a new substrate was used to develop a peroxidase-linked spectrophotometric assay. 4-(trifluoromethyl) benzylamine (11) was proved to be an exc...

one-pot reaction of aldehydes or ketons with aniline derivatives was performed using nabh4 and fe3o4 magnetic nanoparticles (mnps). the optimum amount of fe3o4 mnps was 5 mol% under solvent free condition. the corresponding products were obtained in good to excellent yields. the magnetically recoverable iron oxide nanoparticles are found to be efficient for synthesis of amine derivatives. these...