Background Estimating health-economic impact of new therapies for prodromal Alzheimer’s disease (AD) requires extrapolating short-term effects on surrogate markers efficacy to long-term clinically relevant outcomes. This assumptions the nature treatment (symptomatic versus disease-modifying) and depends target population (which varies in progression associated biological subtypes). We aim estim...

abstract aim and background: the purpose of the present study was to investigate the factorial structure, reliability and divergent and convergent validity of the extended life orientation test- persian version (elot-p). methods and materials: first, elot was translated to persian language. then by using the back-translation procedure, the gaps between the translated version and the original ve...