BACKGROUND Low drug entrapment efficiency of hydrophilic drugs into poly(lactic-co-glycolic acid) (PLGA) nanoparticles is a major drawback. The objective of this work was to investigate different methods of producing PLGA nanoparticles containing minocycline, a drug suitable for periodontal infections. METHODS Different methods, such as single and double solvent evaporation emulsion, ion pair...

in this paper, a new fractional sub-equation method is proposed for finding exact solutions of fractional partial differential equations (fpdes) in the sense of modified riemann-liouville derivative. with the aid of symbolic computation, we choose the space-time fractional zakharov-kuznetsov-benjamin-bona-mahony (zkbbm) equation in mathematical physics with a source to illustrate the validity a...

a modified f-expansion method to find the exact traveling wave solutions of  two-component nonlinear partial differential equations (nlpdes) is discussed. we use this method to construct many new solutions to the nonlinear whitham-broer-kaup system (1+1)-dimensional. the solutions obtained include jacobi elliptic periodic wave solutions which exactly degenerate to the soliton solutions, triangu...

Abstract Tiger nut (Cyperus esculentus L.) is an ideal raw material for oil extraction, but starch-rich tiger meal, a by-product of has not been fully utilized. For this, starch was isolated from and then nanoparticles were prepared by gelatinization, ultrasonication nanoprecipitation under different conditions. The preparation parameters optimized measuring the particle size with dynamic light...

the first aim of the present investigation was to prepare solid dispersions to improve the dissolution properties of oxcarbazepine and quetiapine using peg 6000 as a carrier with the help of two methods of preparations viz. spray drying and modified solvent method, and to compare the two methods. the second objective was to apply the modified solvent method for preparation of sustained release ...

The purpose in this study was to investigate poly(ethylene glycol)-modified poly (d,l-lactide-co-glycolide) nanoparticles (PLGA-PEG-NPs) loading 9-nitrocamptothecin (9-NC) as a potent anticancer drug. 9-NC is an analog of the natural plant alkaloid camptothecin that has shown high antitumor activity and is currently in the end stage of clinical trial. Unfortunately, at physiological pH, these p...

The interest on plants has been focalized due to their biological activities. Extracts or fractions from plants in biodegradable polymeric nanoparticles (NP) provide many advantages on application studies. The encapsulation of the extract or fraction in NP is determined for the establishment of the test dose. HPLC method is an alternative to calculate this parameter. An analytical method based ...

The purpose of this study was to develop Cremophor EL-free nanoparticles loaded with Paclitaxel (PTX), intended to be intravenously administered, able to improve the therapeutic index of the drug and devoid of the adverse effects of Cremophor EL. PTX-loaded PEGylated PLGA-based were prepared by simple emulsion and nanoprecipitation. The incorporation efficiency of PTX was higher with the nanopr...