We reported previously that a 2' fluoro-modified (2' F) phosphorothioate (PS) antisense oligonucleotides (ASOs) with 5-10-5 gapmer configuration interacted with proteins from Drosophila behavior/human splicing (DBHS) family with higher affinity than PS-ASOs modified with 2'-O-(2-methoxyethyl) (2' MOE) or 2',4'-constrained 2'-O-ethyl (cEt) did. Rapid degradation of these proteins and cytotoxicit...

Abstract This paper is based on the study of compact stars in context electric fields and nonmetricity effects gravity. Due to this, we are motivated build stellar models spherically symmetric space-time f ( Q ) The solution obtained by Durgapal Bannerji (Phys Rev D 27:328–331,1983) potential along with modified Van der Waals equation state (EoS) $$p_r=\eta \rho ^2+ \frac{\beta }{\gamma +1}$$ <...

OBJECTIVE We aimed to investigate the ureter stone treatment results performed by using different- caliber semirigid ureteroscopes (URS). MATERIAL AND METHODS Adult patients who were treated for ureteral stones by a single endoscopist between January 2000 and March 2015 were analyzed. The patients were divided into 3 groups in accordance with the caliber of the ureteroscope used: 10/10.5 F St...

This paper studies the third problem for the Laplace equation on a bounded planar domain with inside cracks. The third condition ∂u/∂n+hu= f is given on the boundary of the domain. The skip of the function u+ − u− = g and the modified skip of the normal derivatives (∂u/∂n)+− (∂u/∂n)− +hu+ = f are given on cracks. The solution is looked for in the form of the sum of a modified single-layer poten...

This paper presents an overview of both T-Trefftz and F-Trefftz finite element methods (FEM) and its application in various engineering problems. Recent developments on the T-Trefftz finite element formulation of nonlinear problems of minimal surface, F-Trefftz methods for composite, skin tissue, and functionally graded materials are described. Formulations for all cases are derived by means of...

he F/A-18 Program Office is large and complex. Many pressures and initiatives have compelled the office to institute new management techniques and practices. The prime contractors for the F/A-18—General Electric Aircraft Engines and McDonnell Douglas Aerospace—have also modified their practices to meet today’s changing business environment. This article suggests some new ways of doing business ...

Abstract The gravitino problem is investigated in the framework of extended gravity cosmologies. In particular, we consider f ( R ) gravity, most natural extension Hilbert–Einstein action, and $$f({\mathcal{T}})$$ f ( T ) teleparallel e...

In this paper we show that power-law inflation can be realized in non-minimal gravitational coupling of electromagnetic field with a general function of Gauss-Bonnet invariant. Such a non-minimal coupling may appear due to quantum corrections. We also consider modified Maxwell-F (G) gravity in which non-minimal coupling between electromagnetic field and f (G) occur in the framework of modified ...