Visualizing impacts of an optimization pass helps to reason about, and to gain insight into, the inner workings of the optimization pass. In this paper, we visualize the impacts of two procedural abstraction passes. For this, we modified two procedural abstraction post pass optimizers to visualize for each the difference in machine code before and after optimization by drawing abstracted fragme...

This study was undertaken to identify the signaling events involved in activation of neutrophil superoxide anion (O2-) production by eosinophil granule major basic protein (MBP). MBP did not produce an immediate increase in the cytosolic free calcium concentration ([Ca2+]i), characteristic of phospholipase C activation, but did cause a gradual increase in [Ca2+]i in cytochalasin B-treated cells...

In 2001 the first Brazilian guidelines for the use of home monitoring of blood pressure (HMBP) were published. Those guidelines stated that although a number of HMBP protocols were in use at the time, there was no standard pattern. Recommendation was then for at least two measures in the morning before medications and before breakfast -, and two in the evening before dinner or three hours after...

Oral administration of autoantigens is a safe and convenient way to induce peripheral T-cell tolerance in autoimmune diseases like multiple sclerosis (MS). To increase the efficacy of oral tolerance induction and obviate the need for large-scale purification of human myelin proteins, we use genetically modified lactobacilli expressing myelin antigens. A panel of recombinant lactobacilli was con...

Tumor overexpressed gene (TOG) protein, encoded by cytoskeleton-associated protein CKAP5, is a microtubule-associated protein that binds to heterogeneous nuclear ribonucleoprotein (hnRNP) A2. hnRNP A2 is an RNA trafficking factor that associates with myelin basic protein (MBP) mRNA. In oligodendrocytes, TOG, hnRNP A2, and MBP mRNA colocalize in granules that assemble in the perikaryon and are t...

Maltose-binding protein (MBP) is a critical player of the maltose/maltodextrin transport system in Escherichia coli. Our previous studies have revealed that MBP nonspecifically induces T helper type 1 (Th1) cell activation and activates peritoneal macrophages obtained from mouse. In the present study, we reported a direct stimulatory effect of MBP on RAW264.7 cells, a murine macrophage cell lin...

The c-myc promoter binding protein (MBP-1) was identified previously from a human cervical carcinoma cell (HeLa) cDNA expression library (R. Ray and D. M. Miller, Mol. Cell. Biol., 11: 2154-2161, 1991). This study demonstrated that MBP-1 binds to the mouse c-myc P2 TATA box sequences and exerts a negative regulatory role on c-myc transcription. The role of MBP-1 on cell growth was initially exa...

Backward error analysis has become an important tool for understanding the long time behavior of numerical integration methods. This is true in particular for the integration of Hamiltonian systems where backward error analysis can be used to show that a symplectic method will conserve energy over exponentially long periods of time. Such results are typically based on two aspects of backward er...

This article presents a new learning methodology based on a hybrid algorithm for interval type-2 TSK fuzzy logic systems (FLS). Using input-output data pairs during the forward pass of the training process, the interval type-2 TSK FLS output is calculated and the consequent parameters are estimated by recursive least-squares (RLS) method. In the backward pass, the error propagates backward, and...