objective(s): increased levels of nitric oxide (no) in the testicular veins of people suffering from varicocele have already been reported. however, the role of no-synthase (nos) isozymes and their inhibitors have not been extensively studied. we aimed to evaluate the inhibitory effects of aminoguanidine (ag), on sperm motility, vitality, and mitochondrial membrane potential (mmp) in varicoceli...

OBJECTIVE Matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinases (TIMP) have been found in high concentrations in pleural effusions. Because MMP and TIMP may play a part in the causation of the fibrosis seen in tuberculous (TB) pleuritis their occurrence was examined. DESIGN Pleural effusion fluid and plasma concentrations of MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, TIMP-1 and ...

BACKGROUND Matrix metalloproteinases (MMPs) have been implicated in the invasion and metastasis of head and neck squamous cell carcinoma (HNSCC). However, a detailed analysis of MMPs and tissue inhibitors of MMPs (TIMPs) in relation to the biological behavior of HNSCC has yet to be performed in clinical material. OBJECTIVES To study a comprehensive profile of MMPs and their 2 main inhibitors ...

The invasion of human malignant melanoma cells into the extracellular matrix (ECM) involves the accumulation of proteases at sites of ECM degradation where activation of matrix metalloproteases (MMP) occurs. Here, we show that when membrane type 1 MMP (MT-MMP) was overexpressed in RPMI7951 human melanoma cells, the cells made contact with the ECM, activated soluble and ECM-bound MMP-2, and degr...

Matrix metalloproteinases (MMPs) are proteolytic enzymes that play important roles in cancer progression and metastasis. Although serum MMP expression is known to correlate with the primary lesion of breast cancer, there has yet to be a study regarding the correlation between serum MMP expression and metastatic lesions, particularly lymph nodes. The present study evaluated the correlation of se...

Abstract Background The aim of this study was to determine the temporal evolution extracellular matrix (ECM) remodelling and collagen biomarkers their influence on incisional hernia recurrence after IPOM plus repair. Methods A sub-cohort patients (n=25) undergoing laparoscopic repair within TACKoMesh randomised controlled trial were bled at serial timepoints up 1-year following surgery. Serum/p...

Self-driving technology companies and the research community are accelerating pace of use machine learning longitudinal motion planning (mMP) for autonomous vehicles (AVs). This paper reviews current state art in mMP, with an exclusive focus on its impact traffic congestion. The identifies availability congestion scenarios datasets, summarizes required features training mMP. For methods, major ...

Matrix metalloproteinase 9 (MMP-9) plays an important role in the pathophysiology of inflammation. Several studies have investigated the association between MMP-9 -1562C/T polymorphism and risk of ischemic stroke (IS) where inflammatory process is involved, but the results were inconsistent. Therefore, we first conducted a case-control study to investigate the potential association, and then pe...

PURPOSE To evaluate human corneal epithelial culture supernatant and tear fluid for the presence of activators and inhibitors of matrix metalloproteinase (MMP)-9, MMP-3, and tissue inhibitor of metalloproteinase (TIMP)-1, respectively, and to evaluate the effect of MMP-3 on the activation of MMP-9 in these specimens. METHODS Unstimulated tear fluid was collected from patients with ocular rosa...