Cell signaling processes involve receptor trafficking through highly connected networks of interacting components. The binding of surface receptors to their specific ligands is a key factor for the control and triggering of signaling pathways. In most experimental systems, ligand concentration and cell density vary within a wide range of values. Dependence of the signal response on cell density...

Chelation enables metals to be transported to or from vulnerable target sites, and to hinder or facilitate their carcinogenic potential. In the reverse sense, metals are capable of ligand scavenging via complexation or mixed complex formation--the latter being the result of interaction with binary complexes. Consequently, metal complexes can be utilized for the transport of selected organic che...

Some new mononuclear complexes [ML1L2(NO3)2 ] {where M = [Co(II), Ni(II), Cu(II) and Zn(II)], L1 = 2Hydroxy-5-nitrobenzaldehyde and L2 = diketones (Pentane-2,4-dione, 1-phenylbutane-1,3-dione, 1,3diphenylpropane-1,3-dione)}, have been synthesized and were characterized by elemental analysis, molar conductance, , FTIR spectra, UV, magnetic moment and thermo gravimetric analysis (TGA). The relati...

A method, involving the use of an advanced paper ionophoretic technique is described for the study of equilibria in mixed complex systems in solution. The method is based on the migration of a spot of metal ion, with the complexants added in the background electrolyte. The concentration of one of the complexants, methylcysteine, is kept constant while that of the second ligand, cysteine, is var...

The synthesis and characterization of a mixed metal ruthenium(ii)/gold(iii) complex bridged by tetrapyridophenazine (tpphz) are described. It is isostructural and isoelectronic to the well-known photocatalysts with palladium(ii) or platinum(ii). Concentration dependent (1)H-NMR spectroscopy and XRD studies show that the electrostatic repulsion between the gold(iii) moieties exceeds the attracti...

The two new complexes Ag(L1) L2(PF6)2[Complex (1) and Cu(L1) L2(PF6)2[Complex (2)] containing bioactive mixed ligand of typeL1=8-Hydroxyquinoline and L2=1,10Phenanthroline have been synthesized and characterized by analytical and spectral methods. The binding constant of the complexes in 5 mM Tris-HCl/50 mM NaCl buffer at pH 7.2, are 25.79 x 10 Mand 9.95 x 10 Mfor complex (1) and (2) respective...