Proteins keep Cdc55 in its place R ossio and Yoshida reveal how cells control the location of the mitosis-regulating protein Cdc55. Cdc55 is a key component of the protein phosphatase 2A (PP2A) complex, which helps determine when cells begin and end mitosis. Two other proteins, Zds1 and Zds2, keep the complex under control. They switch on PP2A to nudge the cell into mitosis and switch it off to...

We have used microinjection and time-lapse video microscopy to study the role of cyclin A in mitosis. We have injected purified, active cyclin A/cyclin-dependent kinase 2 (CDK2) into synchronized cells at specific points in the cell cycle and assayed its effect on cell division. We find that cyclin A/CDK2 will drive G2 phase cells into mitosis within 30 min of microinjection, up to 4 h before c...

Rho-Associated kinases ROCK1 and ROCK2 have been extensively investigated in the pathogenesis of cardiovascular disease. However, their roles are not fully understood carcinogenesis. In this study, we whether or is required for survival growth hepatocellular carcinoma (HCC) cells underlying mechanism. ROCKs expression was determined human HCC tissue cell lines using qRT-PCR, western blotting, i...