OBJECTIVES Lutetium-177 can be made with high specific activity and with no other isotopes of lutetium present, referred to as "No Carrier Added" (NCA) 177Lu. We have radiolabelled DOTA-conjugated peptide DOTA-(Tyr3)-octreotate with NCA 177Lu ("NCA-LuTATE") and used it in nearly 40 therapeutic administrations for subjects with neuroendocrine tumours or meningiomas. In this paper, we report on o...

UNLABELLED In patients with a large, multinodular goiter (> 100 g), radiation absorbed doses in the thyroid, surrounding tissues and remainder of the body were estimated after therapeutic administration of 131I(3.7 MBq or 100 microCi/g of thyroid tissue retained at 24 hr). METHODS Thermoluminescent dosimeter (TLD) measurements were performed on 23 patients (12 euthyroid and 1I hyperthyroid; t...

In "What Is the Problem With ThirdParty Prescription for School-Based Practice" (AjOT, Ocrober 1996, pp. 750-751), Royeen discusses the difficulties of third-party therapists involved in me evaluation of a child receiving school-based occupational therapy. I agree with the author that an evaluation void of the school environment is problematic. Frequently, third-party therapists have little awa...

In this paper we report on a successful management of multiple bone metastases from differentiated thyroid cancer. In 2007, a 75-year-old female patient, previously referred for thyroidectomy for multinodular goiter, underwent surgical removal of a lumbar mass with histological findings of metastasis from well differentiated thyroid cancer. After surgery, serum thyroglobulin (sTg) was 204.4 ng/...

BACKGROUND Effective dose represents the potential risk to a population of stochastic effects of ionizing radiation (mainly lethal cancer). In recent years, there have been a number of revisions and updates influencing the way to estimate the effective dose. The aim of this work was to recalculate the effective dose values for the 338 different radiopharmaceuticals previously published by the I...

PET uses specific molecules labelled with positron-emitting radionuclides to provide valuable biochemical and physiological information. However, the administration of radiotracers to patients exposes them to low-dose ionizing radiation, which is a concern in the paediatric population since children are at a higher cancer risk from radiation exposure than adults. Therefore, radiation dosimety c...

background: recent pre-clinical and clinical studies indicate that irradiation in the dose range of 15 to 30 gy can reduce rate of restenosis in patients who have undergone an angioplasty. the use of filled balloon with radioactive solution was proposed as one of the possible intravascular irradiation techniques. materials and methods: the monte carlo n-particle transport code (mcnp4b) was used...

Abstract Purpose A 2-m axial field-of-view, total-body PET/CT scanner (uEXPLORER) has been recently developed to provide coverage and ultra-high sensitivity, which together, enables opportunities for in vivo time-activity curve (TAC) measurement of all investigated organs simultaneously with high temporal resolution. This study aims at quantifying the cumulated activity patient dose 2-[F-18]flu...

To identify effects of transarterial radioembolization (TARE) with Yttrium-90 resin microspheres on histopathological analysis. All patients who underwent TARE to any liver tumor followed by a resection were included in this retrospective, IRB-approved study (n = 26). was performed using 3-day pre-calibration 90Y SPECT/CT or PET/CT. Pathologic analysis board certified pathologist 34 years exper...