نتایج جستجو برای: mir vali
تعداد نتایج: 45799 فیلتر نتایج به سال:
Objective(s): microRNAs are small non-coding molecules that regulate gene expression in various biological processes. T-cell acute lymphoblastic leukemia (T-ALL) is a malignancy accompanied with genetic aberrations and accounts for 20% of children’s and adult’s ALL. Notch signaling pathway dysregulation occurs in 60% of T-ALL cases. In the present study, we aimed to de...
Background: Clear cell renal cell carcinoma (ccRCC) represents approximately 70% of RCC,as the most frequent histological subtype of RCC. MiR-138-5p, a tumor-related microRNA (miRNA), has been reported to be implicated in the diverse types of human malignancies, but its role in ccRCCremains unclear. Objective: The study was designed to investigate the function...
Evaluation of miR-101 Level in Patients with Chronic Hepatitis B Virus Infection and Liver Cirrhosis
ABSTRACT Background and Objective: MiRNAs are small RNAs that are expressed in most eukaryotes, and can regulate gene expression by attaching to the 3’ end of target mRNA. MicroRNA-101 (miR-101) post-transcriptional regulation is important for host-virus interactions. In addition, miR-101 has a tumor suppressive role in liver cancer and metastasis, an...
Multiple sclerosis (MS) is an inflammatory disease that affects the central nervous system. MicroRNAs (miRNAs) are small non-coding RNAs that are usually 18-24 nucleotides long, which may have a pivotal role in the expansion of many complex diseases. The objective of this study was to evaluate the transcript levels of miR-193b-3p and miR-376a-3p in relapsing-remitting multiple sclerosis (RRMS) ...
Background: Safe and effective gene therapy is considered as one of the therapeutic goals in many diseases. Due to the important role of stem cells in cell therapy, this study aimed to produce human adipose-derived mesenchymal stem cells (hASCs) using the miR-34a overexpression. Materials and methods: The hsa-mir-34a precursor sequence was cloned into the PCDH lentiviral vector. The recombinant...
Background and Objective: Aging like many complex traits is the result of interaction between genome and environmental factors and epigenetic mechanisms as a central connector links these two markers. So far, investigations on age-related characteristics and biomarkers predicting survival and risk of death have been carried out, none of which led to an overall consensus among the researchers. I...
Background: Metastasis associated miRNA (metastamiR) opened a new field of anti-metastatic therapy which have a great potential of treatment for the most lethal aspect of cancer, metastasis. The pleiotropic nature of gene regulation exhibited by certain miRNAs that showed that miRNAs might be endowed with a capacity to function as crucial modulators of tumor metastasis. MiR-31 is a pleiotropic ...
زمینه و هدف: در این مطالعه تأثیر تمرینات تناوبی خیلی شدید بربیان ژن خانواده mir-29 که در قلب بیان شده و در فرآیندهای فیزیولوژیکی از جمله تنظیم ماتریکس برون سلولی شرکت می کند و نیز هایپرتروفی قلبی رت های نر سالم مورد آزمایش قرار گرفت. روش بررسی: در این پژوهش 16 سر رت نر ویستار تهیه و به دو گروه کنترل (8=n) و تمرین (8=n) تقسیم و اجرای تمرین تناوبی خیلی شدید بر روی تردمیل، پس از یک هفته آشنایی، به...
1. Dept. of Iranian Traditional Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran 2. Dept. of Physiotherapy, La Trobe University, Bundoora, Victoria, Australia 3. School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran 4. Dept. of Rheumatology, Vali-asr Hospital, Imam Khomeini Hospital Complex, Tehran University of Medical...
Wei Song,1 Hillel Zukor,1,2 Shih-Hsiung Lin,1,2 Jacob Hascalovici,1,2 Adrienne Liberman,1 Ayda Tavitian,1,2 Jeannie Mui,4 Hojatollah Vali,4,5 Xin-Kang Tong,3 Sanjeev K. Bhardwaj,6 Lalit K. Srivastava,6 Edith Hamel,2,3 and Hyman M. Schipper1,2 1Lady Davis Institute, Jewish General Hospital, Montreal, Quebec H3T 1E2, Canada, 2Department of Neurology and Neurosurgery, McGill University, and 3Labor...
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