نتایج جستجو برای: mir 26
تعداد نتایج: 207749 فیلتر نتایج به سال:
A number of studies have attempted to elucidate the association between mircoRNAs (miRNAs/miRs) and cancer-associated processes. The aim of the present study was to determine how miR-499a-5p intervenes in human osteosarcoma cell proliferation and differentiation. The cancerous tissues and adjacent non-cancerous tissues of 62 patients with osteosarcoma (OS) were collected. miRNA microarray analy...
PURPOSE To illustrate the histopathology of keratoconic corneal epithelia and its micro-ribonucleic acid (miRNA) regulation. METHODS Corneal epithelia were collected from 27 patients with keratoconus and 26 normal patients after surgery or by impression cytology. The miRNA profile was determined using miRNA microarray. The biological roles of miRNA target genes were delineated by gene ontolog...
The pathogenesis of nasal polyp is to be further investigated. Micro RNA (miR) plays a role in the development of allergic inflammation. Interleukin (IL)-10-producing dendritic cells (DC) have immune tolerogenic properties. This study test a hypothesis that miR-17-92 cluster is associated with suppressing IL-10 in peripheral DC. In this study, peripheral blood samples were obtained from 26 pati...
The effect of RNA degradation on the diagnostic utility of microRNA has not been systematically evaluated in clinical samples. We asked if the microRNA profile is preserved in degraded RNA samples derived from mouse and human tissue. We selected tissue-specific microRNA candidates from published human microarray data, and validated them using quantitative reverse transcription polymerase chain ...
زمینه و هدف: mirna های مرتبط با متاستاز حوزه جدیدی از درمان های متاستاز بر اساس mir را ایجاد کرده که پتانسیل درمانی بالایی برای کشنده ترین جنبه سرطان، یعنی متاستاز دارد. mir-31 یک mirna ضد متاستازی با عملکرد پلیوتروپیک است که بیان آن در سلول های متاستاتیک سرطان پستان به طور قابل توجهی کاهش می یابد. این mirna در چندین مرحله از آبشار متاستازی نقش دارد و استفاده از روش های بازیافت mir-31 می تواند ...
Human microRNAs (miRs) have been implicated in human diseases presumably through the downregulation and silencing of targeted genes via post-translational modifications. However, their role in the early stage of coronary atherosclerosis is not known. The aim of this study was to test the hypothesis that patients with early atherosclerosis and coronary endothelial dysfunction (CED) have alterati...
Purpose: Recent studies have suggested that microRNA biomarkers could be useful for stratifying lung cancer subtypes, but microRNA signatures varied between different populations. Squamous cell carcinoma (SCC) is one major subtype of lung cancer that urgently needs biomarkers to aid patient management. Here, we undertook the first comprehensive investigation on microRNA in Chinese SCC patients....
Background and purpose: MicroRNA regulation of cancer-related pathways has a major effect on cancer development. MiR-429 is a member of miR-200 family with an important role in metastasis. There are many studies on the association between miR-429 and liver, bladder, bowel, and gastric cancers. In this study, we investigated the expression changes of E2F3 genes after transfection of MCF-7 cells ...
objective(s):micrornas (mirnas) are a class of short rnas that control the biological processes including cell proliferation, apoptosis and development. aberrant expression of mirnas was determined in the different stages of tumor development and metastasis. to study the effect of silibinin on mirnas expression, we evaluated quantitative expression of mir-21 and mir-155 as two oncomirs and seve...
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