The goal of this study is to evaluate if promotion of angiogenesis by systemic treatment with an antagomir against miR-92a, a well established inhibitor of angiogenesis, will maximize the benefits of exercise on bone. Ten week old female C57BL6/J mice were subjected to two weeks of external load by four point bending. During the first week of mechanical loading (ML), mice were injected (2.7 mg/...

objective(s):micrornas (mirnas) are a class of short rnas that control the biological processes including cell proliferation, apoptosis and development. aberrant expression of mirnas was determined in the different stages of tumor development and metastasis. to study the effect of silibinin on mirnas expression, we evaluated quantitative expression of mir-21 and mir-155 as two oncomirs and seve...

Sommario Il diabete mellito di tipo 2 (DMT2) è una malattia metabolica cronica eterogenea in costante aumento. In questa rassegna, al fine identificare un gruppo microRNA (miRNA) con potenziale applicazione clinica come biomarcatori per la diagnosi, prognosi e selezione terapie personalizzate i pazienti DMT2, abbiamo effettuato ricerca sistematica letteratura, identificando selezionando 10 miRN...

There is a lack of biomarkers sepsis and the resuscitation status. Our objective was to prove that serum expression certain microribonucleic acids (miRNAs) differentially regulated in sensitive different regimes. Anesthetized pigs (Sus scrofa domesticus) received no treatment (n = 15) or intravenous live E. coli 24). The septic animals 0.9% saline at 4 mL/kg/h 8) (low group (LoR)) 10–17 (high (...

MicroRNAs (miRNAs) are small non-coding RNAs that function as post-transcriptional gene expression regulators. The expression profiling of miRNAs has already entered into cancer clinics as diagnostic and prognostic biomarkers to assess tumor initiation, progression and response to treatment in cancer patients. Recent Studies opened the way for the use of circulating miRNAs as non-invasive diagn...

We present mid-infrared (MIR) maps for a sample of 18 early-type galaxies observed at 4.5, 6.7 and 15 μm with the ISOCAM instrument on board the ISO satellite with a 6” spatial resolution. We model the Spectral Energy Distribution (SED) of these galaxies using the stellar evolutionary synthesis model PÉGASE and we derive the MIR excess over the stellar component. We then explore the nature of t...

MicroRNAs (miRNAs) play an important role in regulating gene expression and immune responses. Of interest, miR-181a and miR-146a are key players in regulating immune responses and are among the most abundant miRNAs expressed in NK cells. Bioinformatically, we predicted miR-181a to regulate the expression of the natural cytotoxicity receptor NCR2 by seeded interaction with the 3'-untranslated re...

Clear cell papillary renal cell carcinoma (CCPRCC) is a low-grade renal neoplasm with morphological characteristics mimicking both clear cell renal cell carcinoma (CCRCC) and papillary renal cell carcinoma (PRCC). However, despite some overlapping features, their morphological, immunohistochemical, and molecular profiles are distinct. Micro-RNAs (miRNAs) are small noncoding RNAs that play a cru...