Minimum lethal concentrations (MLC) and minimum inhibitory concentrations (MIC) were determined in vitro for 8 antibiotics against 9 isolates of Mycoplasma synoviae. Of the antibiotics tested, tylosin had the highest activity, followed closely by chlortetracycline, lincomycin, oxytetracycline, spectinomycin, and tetracycline. Neomycin and erythromycin were less effective. Two antibiotic combina...

The antimicrobial susceptibility of gonococci isolated in Singapore has been studied over several years. In 1983, the prevalence of penicillinase producing Neisseria gonorrhoeae (PPNG) was 33.5% and 64% of non-PPNG isolates had minimum inhibitory concentrations (MICs) of penicillin of greater than or equal to 0.5 mg/l. After a control programme, the isolation of the gonococcus from prostitutes ...

A series of bis-pyridinium quaternary ammonium salts (bis-PyQAs) with different aryl and heteroaryl moieties were synthesized and their antimicrobial activity investigated. The inhibition effect of the compounds was evaluated against bacteria, molds and yeasts; the activities were expressed as the minimum inhibitory concentrations (MIC). The relationships between the structure descriptors (logP...

In vitro activities of linezolid and vancomycin which were evaluated against methicill in resistant Staphylococcus aureus (MRSA). One hundred clinical isolates of MRSA were collected. The minimum inhibitory concentrations (MICs) of linezolid and vancomycin were determined by the Epsilon-test method. The results showed 100 percent susceptibility of linezolid and vancomycin against MRSA isolates....

Emergence of resistance among pathogenic bacteria against available antibiotics is posing a great challenge to the current world. Thus, there is a great need to discover novel antibiotics. Traditional plants have been proved to be novel source in the search of antimicrobial compounds. The current study pertained to the susceptibilities of some clinically significant bacterial species to various...

The main objective of this investigation is to find out the minimum inhibitory concentration (MIC) of Staphylococcus aureus with reduced inclination to vancomycin among 30 clinical isolates of methicillin-resistance Staphylococcus aureus (MRSA) and was screened by Etest and broth dilution methods. The comparative analysis of MIC for vancomycin by broth dilution and Etest methods discloses that ...

Forty-two isolates of Bacteroides fragilis were tested against five new cephalosporin antibiotics by two quantitative methods, microdilution and agar dilution. Results indicated satisfactory methodological agreement. Mean minimum inhibitory concentrations (MIC) of thienamycin, moxalactam, and ceftizoxime were significantly lower than with the other antibiotics tested.

This research aims to study the production of chitosan from shrimp shell (Litopenaeus vannamei) of waste origin using two chemical methodologies involving demineralization, deproteinization, and the degree of deacetylation. The evaluation of the quality of chitosan from waste shrimp shells includes parameters for the yield, physical chemistry characteristics by infrared spectroscopy (FT-IR), th...

Tuberculosis is a serious global health problem caused by the bacterium Mycobacterium tuberculosis. There is an urgent need for discovery and development of new treatments, but this can only be accomplished through rapid and reproducible M. tuberculosis assays designed to identify potent inhibitors. We developed an automated 96-well assay utilizing a recombinant strain of M. tuberculosis expres...

We studied the impact of a sublethal concentration of erythromycin on the fitness and proteome of a continuously cultivated population of Escherichia coli. The development of resistance to erythromycin in the population was followed over time by the gradient plate method and minimum inhibitory concentration (MIC) measurements. We measured the growth rate, standardized efficiency of synthesis of...