http://ccn.aacnjournals.org H ypothermia can occur not only in persons exposed to extreme cold, but also in the elderly and infirm, and in patients with medical conditions that impair the ability to maintain an adequate body temperature. Stages of hypothermia are classified as mild, moderate, and severe (Table 1). Treatments for hypothermia have been described since the time of Hippocrates (470...

BACKGROUND AND PURPOSE Both hypothermia and decompressive craniectomy (DC) have been shown to reduce ischemic injury in experimental middle cerebral artery (MCA) infarction. This study was designed to evaluate the effect of combined DC and hypothermia on infarction size and neurological outcome in a rat model of MCA occlusion (MCAO). METHODS MCAO was performed in 72 Wistar rats assigned to gr...

Despite the positive effects of mild hypothermic conditions on monoclonal antibody (mAb) productivity (qmAb ) during mammalian cell culture, the impact of reduced culture temperature on mAb Fc-glycosylation and the mechanism behind changes in the glycan composition are not fully established. The lack of knowledge about the regulation of dynamic intracellular processes under mild hypothermia res...

The head warming in hypothermic victims is an alternative way of heat donation, which does not inhibit shivering and does not impede the access to the patient's chest. It seems to be a safe method in mild hypothermia. The authors of the review article "Accidental hypothermia - an update" suggest this way of heat donation, without indicating precisely, in which group of patients it can be applie...

BACKGROUND The purpose of this study was to determine the effect of mild hypothermia therapy on gastric mucosa after cardiopulmonary resuscitation (CPR) and the underlying mechanism. MATERIAL AND METHODS Ventricular fibrillation was induced in pigs. After CPR, the surviving pigs were divided into mild hypothermia-treated and control groups. The changes in vital signs and hemodynamic parameters ...

1. The Hypothermia After Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002;346:549 –56. 2. Bernard SA, Gray TW, Buist MD, et al. Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. N Engl J Med 2002;346:557– 63. 3. Boddicker KA, Zhang Y, Zimmerman MB, Davies LR, Kerber RE. Hy...

BACKGROUND Emergency Medical Services (EMS) has started to embrace the early use of therapeutic hypothermia as standard treatment to improve neurological recovery in out-of hospital cardiac arrest (OHCA) survivors. OBJECTIVE We conducted a systematic review to provide an overall description of the current literature on the use of therapeutic hypothermia in OHCA and to identify possible gaps i...

STUDY OBJECTIVES In this study, we determined the effects of various body temperatures (BTs) after initiation of lipopolysaccharide (LPS)-induced lung injury. DESIGN AND SETTING Forty-nine, adult, male, Sprague-Dawley rats each weighing 300 to 400 g were used METHODS The treated rats were challenged with intraperitoneal (IP) administration of 5 mg/kg LPS. Control animals received IP saline ...

BACKGROUND Cold injuries are rare but important causes of hospitalization. We aimed to identify the magnitude of cold injury hospitalization, and assess causes, associated factors and treatment routines in a subarctic region. METHODS In this retrospective analysis of hospital records from the 4 northernmost counties in Sweden, cases from 2000-2007 were identified from the hospital registry by...