نتایج جستجو برای: microrna ها

تعداد نتایج: 378343  

Journal: :Journal of the American Society of Nephrology : JASN 2016
Qingqing Wei Yong Liu Pengyuan Liu Jielu Hao Mingyu Liang Qing-Sheng Mi Jian-Kang Chen Zheng Dong

MicroRNAs have been implicated in ischemic AKI. However, the specific microRNA species that regulates ischemic kidney injury remains unidentified. Our previous microarray analysis revealed microRNA-489 induction in kidneys of mice subjected to renal ischemia-reperfusion. In this study, we verified the induction of microRNA-489 during ischemic AKI in mice and further examined the underlying mech...

Journal: :Journal of leukocyte biology 2016
Jeffrey L Kurkewich Emmanuel Bikorimana Tan Nguyen Nathan Klopfenstein Helen Zhang William M Hallas Gwen Stayback Mary Ann McDowell Richard Dahl

Ablation of microRNA synthesis by deletion of the microRNA-processing enzyme Dicer has demonstrated that microRNAs are necessary for normal hematopoietic differentiation and function. However, it is still unclear which specific microRNAs are required for hematopoiesis and at what developmental stages they are necessary. This is especially true for immune cell development. We previously observed...

Journal: :International journal of clinical and experimental pathology 2015
Liqiong Yao Zhiwu Liu Jinhong Zhu Bin Li Chen Chai Yunlin Tian

OBJECTIVE To investigated the circulating microRNA expression profile in sepsis and its clinical evaluation. METHODS 70 patients with sepsis and 30 patients with SIRS were selected and their blood samples were collected. Using liquid bead array with 3 statistical analysis approaches analyzed the circulating microRNA expression profiles, for confirming the data of liquid bead array, qRT-PCR wa...

Journal: :Journal of the American Society of Nephrology : JASN 2012
Yi-Fan Lan Hsi-Hsien Chen Pei-Fang Lai Ching-Feng Cheng Yen-Ta Huang Yi-Chao Lee Tzen-Wen Chen Heng Lin

MicroRNA-494 mediates apoptosis and necrosis in several types of cells, but its renal target and potential role in AKI are unknown. Here, we found that microRNA-494 binds to the 3'UTR of activating transcription factor 3 (ATF3) and decreases its transcription. In mice, overexpression of microRNA-494 significantly attenuated the level of ATF3 and induced inflammatory mediators, such as IL-6, mon...

2011
Hasan Ogul Sinan U. Umu Y. Yener Tuncel Mahinur S. Akkaya

Elucidation of microRNA activity is a crucial step in understanding gene regulation. One key problem in this effort is how to model the pairwise interaction of microRNAs with their targets. As this interaction is strongly mediated by their sequences, it is desired to set up a probabilistic model to explain the binding between a microRNA sequence and the sequence of a putative target. To this en...

2013
Antonio Marco Maria Ninova Matthew Ronshaugen Sam Griffiths-Jones

Genetic linkage may result in the expression of multiple products from a polycistronic transcript, under the control of a single promoter. In animals, protein-coding polycistronic transcripts are rare. However, microRNAs are frequently clustered in the genomes of animals, and these clusters are often transcribed as a single unit. The evolution of microRNA clusters has been the subject of much s...

2010
Leigh-Ann MacFarlane Paul R. Murphy

MicroRNAs are small, highly conserved non-coding RNA molecules involved in the regulation of gene expression. MicroRNAs are transcribed by RNA polymerases II and III, generating precursors that undergo a series of cleavage events to form mature microRNA. The conventional biogenesis pathway consists of two cleavage events, one nuclear and one cytoplasmic. However, alternative biogenesis pathways...

Hadi Zare-Zardini, Mehri Khatami, Mohammad Mehdi Heidari, Parisa Naji, Reyhane Chamani,

MicroRNAs (miRNAs, miRs) are small endogenous non-coding RNAs that regulate the expression of protein-encoding genes at the post-transcriptional level. Several studies have described the role of miRNAs in T-cell acute lymphoblastic leukemia (T-ALL), including tumor suppressor and oncogenic miRNAs. Down-regulation of miRNA expression is a prominent feature of human malignancy. This down-regulati...

Journal: :Cardiovascular research 2012
Yung-Song Wang Hay-Yan J Wang Yi-Chu Liao Pei-Chien Tsai Ku-Chung Chen Hsin-Yun Cheng Ruey-Tay Lin Suh-Hang Hank Juo

AIMS Proliferation and migration of vascular smooth muscle cells (VSMCs) can cause atherosclerosis and neointimal formation. MicroRNAs have been shown to regulate cell proliferation and phenotype transformation. We discovered abundant expression of microRNA-195 in VSMCs and conducted a series of studies to identify its function in the cardiovascular system. METHODS AND RESULTS MicroRNA-195 ex...

Journal: :PLoS ONE 2009
Fumiaki Sato Soken Tsuchiya Kazuya Terasawa Gozoh Tsujimoto

Over the last decade, DNA microarray technology has provided a great contribution to the life sciences. The MicroArray Quality Control (MAQC) project demonstrated the way to analyze the expression microarray. Recently, microarray technology has been utilized to analyze a comprehensive microRNA expression profiling. Currently, several platforms of microRNA microarray chips are commercially avail...

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